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GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation
(2015-12-01)
Strategies aimed at mimicking or enhancing the action of the incretin hormone glucagon-like peptide 1 (GLP-1) therapeutically improve glucose-stimulated insulin secretion (GSIS); however, it is not clear whether GLP-1 ...
Adjunctive therapies to reduce thrombotic events in patients with a history of myocardial infarction : role of vorapaxar
(2015-07-22)
Acute myocardial infarction (AMI) is generally attributed to coronary atherothrombotic disease. Platelet activation is essential for thrombus formation and is thus an important target for pharmacological intervention to ...
Quercetin Affects Erythropoiesis and Heart Mitochondrial Function in Mice
(2015-05-28)
Quercetin, a dietary flavonoid used as a food supplement, showed powerful antioxidant effects in different cellular models. However, recent in vitro and in vivo studies in mammals have suggested a prooxidant effect of ...