Now showing items 1-10 of 23
Investigations into the formulation of metered dose inhalers of salmeterol xinafoate and fluticasone propionate microcrystals
Purpose. To investigate the aerosolization and behaviour of microparticles of salmeterol xinafoate (SX) and fluticasone propionate (FP) suspended in hydrofluoroalkane (HFA) propellant. Methods. Microcrystals of SX and FP ...
Reliability of human cryopreserved hepatocytes and liver microsomes as in vitro systems to predict metabolic clearance
A total of 110 drugs, selected to cover a range of physicochemical and pharmacokinetic properties, were used to explore standard approaches to the prediction of in vivo metabolic clearance using drug-depletion profiles ...
An investigation into solvent-membrane interactions when assessing drug release from organic vehicles using regenerated cellulose membranes
The influence of organic solvents on artificial membranes when assessing drug release from topical formulations is, generally, poorly characterised yet current guidelines require no characterisation of the membrane before, ...
Teaching pharmacies are a crucial innovation
Effect of abrasion induced by a rotating brush on the skin permeation of solutes with varying physicochemical properties
A transient reduction in the barrier nature of the skin can be a pre-requisite for successful (trans)dermal delivery of some drugs. The aim of this present study was to investigate and effect of a dermal abrading "rotating ...
Decontamination of multiple casualties who are chemically contaminated : a challenge for acute hospitals
Patients who have been contaminated by chemical compounds present a number of difficulties to emergency departments, in particular, the risk of secondary contamination of healthcare staff and facilities. The Department of ...
Cost efficacy in measuring farmland biodiversity : lessons from the Farm Scale Evaluations of GMHT crops
Measuring farmland biodiversity is time-consuming and costly. Operational data from the Farm Scale Evaluation of genetically modified crops project were collated to identify the financial and time costs of each of the 14 ...
In vitro susceptibility of genotypically distinct and clonal Clostridium difficile strains to oritavancin
Clostridium difficile infection is a nosocomial disease of increasing importance. First-line treatment is limited to metronidazole or vancomycin. Oritavancin is a lipoglycopeptide with activity against Gram-positive bacteria, ...
Sustainable food systems in Europe : policies, realities and futures
This article reviews the food sustainability challenges facing the 27-nation member European Union (EU). It describes the evolution of sustainable development policy in Europe against the background of the EU's evolution ...