Browsing Research publications by Author "Lou, Fang"
Now showing items 21-24 of 24
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Shortening during stimulation vs. during relaxation : How do the costs compare?
Lou, Fang; Curtin, N.A.; Woledge, R.C. (1998)White muscle fibres from dogfish were used to investigate the energetic cost of shortening by fully active muscle and by relaxing muscle. The muscle preparation was tetanized for 0.6 s and shortened by 1 mm (about 15% L0) ... -
Sustained performance by red and white muscle fibres from the dogfish Scyliorhinus canicula
Curtin, N.A.; Lou, Fang; Woledge, R.C. (2010-06-01)The mechanical performance of red and white muscle fibres from dogfish was compared during a long series of contractions with sinusoidal movement or under isometric conditions at 12 degrees C (normal in vivo temperature). ... -
Systemic delivery of morpholino oligonucleotide restores dystrophin expression bodywide and improves dystrophic pathology
Alter, Julia; Lou, Fang; Rabinowitz, Adam; Yin, HaiFang; Rosenfeld, Jeffrey; Wilton, Steve D; Partridge, Terence A; Lu, Qi Long (2006)For the majority of Duchenne muscular dystrophy (DMD) mutations, antisense oligonucleotide (AON)-mediated exon skipping has the potential to restore a functional protein. Here we show that weekly intravenous injections of ... -
Variation in myoplasmic Ca2+ concentration during contraction and relaxation studied by the indicator fluo-3 in frog muscle fibres
Caputo, C.; Edman, K.A.P.; Lou, Fang; Sun, Y-B. (1994-07-01)1. The fluorescent dye fluo-3, in its permeant acetoxymethyl form, was used to monitor calcium transients during twitch and tetanus of single fibres isolated from the anterior tibialis muscle of Rana temporaria (2-5 degrees ...