Browsing Research publications by Author "Martin, Gary P."
Now showing items 21-40 of 41
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An in vitro technique for evaluating inhaled nasal delivery systems
Forbes, B.; Lim, S.; Martin, Gary P.; Brown, Marc (2002)This report describes a novel technique for delivering aerosols to the surface of respiratory epithelial cells cultured tit an air-liquid interface. A model microsphere formulation for nasal delivery was aerosolised using ... -
In vivo evaluation of novel hyaluronan/chitosan microparticulate delivery systems for the nasal delivery of gentamicin in rabbits
Lim, S. T.; Forbes, B.; Berry, D. J.; Martin, Gary P.; Brown, Marc (2002-01)Biodegradable microparticles containing gentamicin were prepared using chitosan hydroglutamate (CH), hyaluronic acid (HA) and a combination Of both polymers by a solvent evaporation method. These formulations were administered ... -
An in-vitro study of the effect of hydrocolloid patch occlusion on the penetration of triamcinolone acetonide through skin in man
Ladenheim, D.; Martin, Gary P.; Marriott, C.; Hollingsbee, D. A.; Brown, Marc (1996-08)The aim of this study was to evaluate the effect of occlusion using hydrocolloid-containing patches on in-vitro triamcinolone acetonide (TACA) penetration of the epidermis while monitoring the uptake of water by the patches ... -
The influence of hydrocolloid patch composition on the bioavailability of triamcinolone acetonide in humans
Martin, Gary P.; Ladenheim, D.; Marriott, C.; Hollingsbee, D.A.; Brown, Marc (2000-01)Triamcinolone acetonide (TACA) is a corticosteroid; it is used in the systemic and topical treatment of a variety of inflammatory conditions, including eczema and psoriasis. Conventionally, for topical use, the drug is ... -
The influence of oily vehicle composition and vehicle-membrane interactions on the diffusion of model permeants across barrier membranes
Najib, Omaima N.; Martin, Gary P.; Kirton, Stewart B.; Botha, Michelle J.; Sallam, Al Sayed; Murnane, Darragh (2021-01-14)In many instances, one or more components of a pharmaceutical or cosmetic formulation is an oil. The aims of this study were two-fold. First, to examine the potential of preferential uptake of one oily vehicle component ... -
An investigation of calibration methods for solution calorimetry
Yff, B. T. S.; Royall, P.G.; Brown, Marc; Martin, Gary P. (2004-01-28)Solution calorimetry has been used in a number of varying applications within pharmaceutical research as a technique for the physical characterisation of pharmaceutical materials, such as quantifying small degrees of ... -
Investigation of the physical properties of spray-dried stabilised lysozyme particles
Liao, Y. H.; Brown, Marc; Quader, A.; Martin, Gary P. (2003-09)The aim of this study was to investigate the effect of the composition of formulations on the physical properties, including glass-transition temperatures (Tg) and aerodynamic-related characteristics, of spray-dried lysozyme ... -
Investigation of the stabilisation of freeze-dried lysozyme and the physical properties of the formulations
Liao, Y. H.; Martin, Gary P.; Brown, Marc (2004-07)The long-term stability of a protein formulation requires that the glass transition temperature (T-g) of the formulation should be maximised and the perturbation of the protein native structure in the dried form after ... -
Investigations into the formulation of metered dose inhalers of salmeterol xinafoate and fluticasone propionate microcrystals
Murnane, Darragh; Martin, Gary P.; Marriott, Christopher (2008-10)Purpose. To investigate the aerosolization and behaviour of microparticles of salmeterol xinafoate (SX) and fluticasone propionate (FP) suspended in hydrofluoroalkane (HFA) propellant. Methods. Microcrystals of SX and FP ... -
Mitigation of surfactant erythrocyte toxicity by egg phosphatidylcholine
Gould, L. A.; Lansley, A. B.; Brown, Marc; Forbes, B.; Martin, Gary P. (2000-10)Polyoxyethylene alkyl ether surfactants have been shown to have excellent penetration enhancing abilities although they are associated with a high level of local toxicity. We have compared the toxicity of a range of ... -
Multivariate analytical approaches to identify key molecular properties of vehicles, permeants and membranes that affect permeation through membranes
Najib, Omaima N.; Kirton, Stewart B.; Martin, Gary P.; Botha, Michelle J.; Sallam, Al Sayed; Murnane, Darragh (2020-10-31)There has been considerable recent interest in employing computer models to investigate the relationship between the structure of a molecule and its dermal penetration. Molecular permeation across the epidermis has previously ... -
Polymorphic control of inhalation microparticles prepared by crystallization
Murnane, Darragh; Marriott, Christopher; Martin, Gary P. (2008-09-01)Milling processes are known to cause polymorphic transition in enantiotropic systems and the micronization process employed to produce microparticles for inhalation formulations has been reported to result in solid-state ... -
A preliminary study of the effect of hyaluronan on the deposition of C-14-labelled diclofenac within human skin using autoradiography
Brown, Marc; Ingham, S.; Moore, A.; Martin, Gary P.; Marriott, C. (Royal Society of Medicine Press, 1995) -
Preparation and evaluation of the in vitro drug release properties and mucoadhesion of novel microspheres of hyaluronic acid and chitosan
Lim, S. T.; Martin, Gary P.; Berry, D. J.; Brown, Marc (2000-05-15)Rapid mucociliary clearance of intranasally administered drugs is often a key factor in determining the bioavailability of such therapeutic agents. The use of mucoadhesive microparticles provide a potential strategy for ... -
Rapid characterisation of the inherent dispersibility of respirable powders using dry dispersion laser diffraction
Jaffari, Sara; Forbes, Ben; Collins, Elizabeth; Barlow, David J.; Martin, Gary P.; Murnane, Darragh (2013-04)Understanding and controlling powder de-agglomeration is of great importance in the development of dry powder inhaler (DPI) products. Dry dispersion laser diffraction measures particle size readily under controlled dispersing ... -
Short-term iontophoretic and post-iontophoretic transport of model penetrants across excised human epidermis
Akomeah, Franklin K.; Martin, Gary P.; Brown, Marc (2009-02-09)The effect of short-term current application (0.4 mA for 10 min) on the epidermal transport of two model penetrants (butyl paraben, BP; caffeine, CF) of differing lipohilicity was investigated and compared to that produced ... -
Stabilisation of deoxyribonuclease in hydrofluoroalkanes using miscible vinyl polymers
Jones, Stuart A.; Martin, Gary P.; Brown, Marc (2006-09-28)A mix of biocompatible macromolecules (poly(vinyl alcohol) (PVA) and poly(vinyl pyrrolidone) (PVP)) has been shown previously to enhance the physical stability of non-aqueous pharmaceutical suspensions. The aim of this ... -
A study of the transdermal drug delivery properties of hyaluronan
Brown, Marc; Marriott, C.; Martin, Gary P. (Royal Society of Medicine Press, 1995) -
Turbidimetric and HPLC assays for the determination of formulated lysozyme activity
Liao, Y. H.; Brown, Marc; Martin, Gary P. (2001-04)In several studies lysozyme has been employed as a model protein to investigate the effects of formulation factors upon biological activity. The aim of this work was to develop and validate an HPLC technique to assay ... -
The use of hyaluronan in transdermal drug delivery : Physiological barriers and regulatory issues
Marriott, C.; Martin, Gary P.; Brown, Marc (Royal Society of Medicine Press, 1995)