Browsing Research publications by Author "Prowse, David M."
Now showing items 21-27 of 27
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Pak1 phosphorylation on T212 affects microtubules in cells undergoing mitosis
Banerjee, M.; Worth, D.; Prowse, David M.; Nikolic, M. (2002-07-23)The Pak kinases are targets of the Rho GTPases Rac and Cdc42, which regulate cell shape and motility [1-5]. It is increasingly apparent that part of this function is due to the effect Pak kinases have on microtubule ... -
Re: Christine McKillop. Interview with Jack Schalken: PCA3 and its Use as a Diagnostic Test in Prostate Cancer. Eur Urol 2006;50:153-154.
Shaw, Greg; Oliver, R. Tim D; Purkiss, Trisha; Prowse, David M. (2007-03-01) -
The retinoblastoma protein/p16INK4A pathway but not p53 is disrupted by human papillomavirus in penile squamous cell carcinoma
Stankiewicz, Elzbieta; Prowse, David M.; Ktori, Elena; Cuzick, Jack; Ambroisine, Laurence; Zhang, Xiaoxi; Kudahetti, Sakunthala; Watkin, Nicholas; Corbishley, Catherine; Berney, Daniel M. (2011-02-01)Aims: The pathogenesis of penile squamous cell carcinoma (PSCC) is not well understood. Human papillomavirus (HPV) may be involved in carcinogenesis, but few studies have compared cell-cycle protein expression in HPV ... -
Transient activation of FOXN1 in keratinocytes induces a transcriptional programme that promotes terminal differentiation : Contrasting roles of FOXN1 and Akt
Janes, Sam M.; Ofstad, Tyler A.; Campbell, Douglas H.; Watt, Fiona M.; Prowse, David M. (2004-08-15)The forkhead transcription factor FOXN1 is required for normal cutaneous and thymic epithelial development. Mutations in FOXN1 give rise to the nude phenotype in mice, rats and man. However, the genes that are regulated ... -
Transient activaton of β-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours
Celso, Cristina Lo; Prowse, David M.; Watt, Fiona M. (2004-04-01)When β-catenin signalling is disturbed from mid-gestation onwards lineage commitment is profoundly altered in postnatal mouse epidermis. We have investigated whether adult epidermis has the capacity for β-catenin-induced ... -
WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics
Bisson, Isabelle; Prowse, David M. (2009-06-01)Prostate cancer cells with stem cell characteristics were identified in human prostate cancer cell lines by their ability to form from single cells self-renewing prostaspheres in non-adherent cultures. Prostaspheres exhibited ... -
β-catenin and hedgehog signal strength can specify number and location of hair follicles in adult epidermis without recruitment of bulge stem cells
Silva-Vargas, Violeta; Lo Celso, Cristina; Giangreco, Adam; Ofstad, Tyler; Prowse, David M.; Braun, Kristin M.; Watt, Fiona M. (2005-07-01)Using K14ΔNβ-cateninER transgenic mice, we show that short-term, low-level β-catenin activation stimulates de novo hair follicle formation from sebaceous glands and interfollicular epidermis, while only sustained, high-level ...