Browsing Research publications by Author "Pharmaceutics"
Now showing items 21-40 of 309
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Branched Copolymer Surfactants as Versatile Templates for Responsive Emulsifiers with Bespoke Temperature‐Triggered Emulsion‐Breaking or Gelation
Rajbanshi, Abhishek; Alves da Silva, Marcelo; Haslett, Niamh; Cranwell, Philippa; Cunningham, Neil; Mahmoudi, Najet; Murnane, Darragh; Pavlova, Ewa; Slouf, Miroslav; Dreiss, Cecile; Cook, Michael (2023-10-27)It has been found that the thermoresponsive behavior of emulsions stabilized by block copolymer surfactants (BCSs) can induce either gelation or emulsion break‐up with mild temperature changes. A hydrophilic, steric‐stabilizing ... -
Can children swallow tablets? Outcome data from a feasibility study to assess the swallowability and acceptability of different sized placebo tablets in children and young people (Creating Acceptable Tablets - CAT)
Bracken, Louise; McDonough, Emma; Ashleigh, Samantha; Wilson, Fiona; Shakeshaft, Joanne; Ohia, Udeme; Mistry, Punam; Jones, Huw; Kanji, Nazim; Liu, Fang; Peak, Matthew (2020-10-10)Objective Feasibility study to investigate the acceptability of different-sized placebo tablets in children aged 4–12 years. Design and setting Clinical Research Facilities, inpatient wards and outpatient clinics within a ... -
Captagon: Use and Trade in the Middle East
Al-Imam, Ahmed; Santacroce, Rita; Roman-Urrestarazu, Andres; Chilcott, Robert; Martinotti, G.; Bersani, Giuseppe; Corazza, Ornella (2017-05-31)Fenetheylline, a psychostimulant drug, often branded as Captagon, is a combination of amphetamine and theophylline. Since the cessation of its legal production in 1986, counterfeited products have been produced illicitly ... -
Carbohydrate Amphiphiles Enable Peptide Delivery to the CNS
Lalatsa, Aikaterini; Schatzlein, A. G.; Uchegbu, I.F. (2008) -
Characterisation of ATP-binding cassette (ABC) transporters in the Calu-3 human bronchial epithelial cell culture model
Hutter, Victoria; Hilgendorf, Constanze; Brown, Alan; Cooper, Anne; Zann, Vanessa; Pritchard, David; Bosquillon, Cynthia (2010-10)Expression and functionality of ATP-binding cassette (ABC) transporters were assessed in Calu-3 cell monolayers cultured at an air-liquid interface. Transporter gene expression was in agreement with published data in human ... -
Characterisation of the Interaction of Lactate Dehydrogenase With Tween-20 Using Isothermal Titration Calorimetry, Interfacial Rheometry and Surface Tension Measurements
Mcauley, William J.; Jones, David S.; Kett, Vicky L. (2009-08)In this study the nature of the interaction between Tween-20 and lactate dehydrogenase (LDH) was investigated using isothermal titration calorimetry (ITC). In addition the effects of the protein and surfactant on the ... -
Characterization of latent heat-releasing phase change materials for dermal therapies
Wood, D.G.; Brown, Marc; Jones, S. A.; Murnane, D. (2011-04-28)Phase change materials (PCMs) have been developed as heat storage solutions, particularly for the supply of “green” energy. One interesting use of PCMs is long-term energy storage, in which a phase transition is triggered ... -
Classification of irritant/ non-irritant and corrosive chemicals using excised human skin in vitro
Stewart, C.A.; Turner, Rob B.; Brown, Marc; Traynor, M.J. (Royal Society of Chemistry, 2014-04-14)Any chemical that is applied to the skin has the potential to induce a skin reaction. These reactions are complicated and are difficult to fully replicate in vitro and may exhibit species variations when reproduced in vivo. ... -
Clinical manifestations of VX poisoning following percutaneous exposure in the domestic white pig
Chilcott, Robert; Dalton, C. H.; Hill, I.; Davidson, C. M.; Blohm, K. L.; Hamilton, M. G. (2003-05)Nerve agents are a class of organophosphorus chemicals that inhibit certain cholinesterase enzymes (ChE). If untreated, percutaneous exposure to nerve agents, such as VX (O-ethyl-S-[2(diisopropylamino)ethyl] methylphosph ... -
Closed cup vapor systems in percutaneous exposure studies : What is the dose?
Dalton, C. H.; Maidment, Michael P.; Jenner, J.; Chilcott, Robert (2006-04)Percutaneous vapor dosing studies have generally used saturated vapor concentration (SVC) measurements to estimate the exposure dose (Ct) of vapor produced from a volatile liquid within a closed system. The purpose of this ... -
Co-Incubation with PPARβ/δ Agonists and Antagonists Modeled Using Computational Chemistry: Effect on LPS Induced Inflammatory Markers in Pulmonary Artery
Perez Diaz, Noelia; Lione, Lisa; Hutter, Victoria; Mackenzie, Louise Susan (MDPI Multidisciplinary Digital Publishing Institute, 2022-05-01)Peroxisome proliferator activated receptor beta/delta (PPARβ/δ) is a nuclear receptor ubiquitously expressed in cells, whose signaling controls inflammation. There are large discrepancies in understanding the complex role ... -
Co-Incubation with PPARβ/δ Agonists and Antagonists Modeled Using Computational Chemistry: Effect on LPS Induced Inflammatory Markers in Pulmonary Artery
Perez Diaz, Noelia; Lione, Lisa; Hutter, Victoria; Mackenzie, Louise Susan (2021-03-19)Peroxisome proliferator activated receptor beta/delta (PPARβ/δ) is a nuclear receptor ubiquitously expressed in cells, whose signaling controls inflammation. There are large discrepan-cies in understanding the complex role ... -
Collection and characterisation of residual skin surface components obtained from sebum, sweat and epidermal lipids
Shetage, S.S.; Traynor, M.J.; Brown, Marc; Chilcott, Robert (Royal Society of Chemistry, 2014-04-14)Collection and analysis of skin surface lipids or sebum has been reported in several previous studies where Sebutape™, polyurethane foam, cigarette paper and organic solvents were used to acquire samples, analysis of which ... -
Combining branched copolymers with additives generates stable thermoresponsive emulsions with in situ gelation upon exposure to body temperature
Rajbanshi, Abhishek; Mahmoudi, Najet; Murnane, Darragh; Pavlova, Ewa; Slouf, Miroslav; Dreiss, Cécile A.; Cook, Michael T. (2023-04-04)Branched copolymer surfactants (BCS) containing thermoresponsive polymer components, hydrophilic components, and hydrophobic termini allow the formation of emulsions which switch from liquid at room temperature to a gel ... -
A comparison of topical formulations for the prevention of human schistosomiasis
Cooper, E.; Iqbal, A.; Bartlett, A.; Marriott, C.; Whitfield, P.J.; Brown, Marc (2004-08)Recently, a dimeticone formulation has been shown to be effective at preventing Schistosoma cercariae infecting skin, while DEET (N,N-diethyl-m-toluamide), a highly effective insecticide, has been shown to have activity ... -
Concordance, adherence or competence – device use and therapeutic outcomes in older patients
Murnane, Darragh (2013)When looking at the needs of the older patient, several issues arise related to the use of medical devices and technologies. Making allowances for physical capacity and cognitive ability, for example, can be crucial to ... -
Controlled Release of Dipyridamole from Floating Matrices Prepared Using Glyceryl Behenate
Patel, Viralkumar; Patel, Natavarlal M. (2008) -
Controlling barrier penetration via exothermic iron oxidation
Wood, Daniel G.; Brown, Marc; Jones, Stuart A. (2011-02-14)Exothermic iron oxidation is an elegant means to generate heat, with the potential to modulate barrier penetration if reaction kinetics can be controlled. This aim of this study was to gain a fundamental understanding of ... -
Controlling the disposition of gallium complexes in human skin using iontophoresis
Staff, K.; Jones, S. A.; Brown, Marc (2010-06) -
The correlation between in-vitro and in-vivo skin permeation models of a novel diclofenac formulation
Van Eyssen, E. G.; Davies, D.; Davis, A.; Brown, Marc (2010-06)