Browsing Research publications by Author "Psychopharmacology, Drug Misuse and Novel Psychoactive Substances Unit"
Now showing items 21-40 of 318
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The benefits of in silico modeling to identify possible small-molecule drugs and their off-target interactions
Zloh, Mire; Kirton, Stewart (2018-02-01)The research into the use of small molecules as drugs continues to be a key driver in the development of molecular databases, computer-aided drug design software and collaborative platforms. The evolution of computational ... -
Benzodiazepine Boom: Tracking Etizolam, Pyrazolam, and Flubromazepam from Pre-UK Psychoactive Act 2016 to Present Using Analytical and Social Listening Techniques
Mullin, Anthony; Scott, Mark; Vaccaro, Giorgia; Floresta, Giuseppe; Arillotta, Davide; Catalani, Valeria; Corkery, John M; Stair, Jacqueline L; Schifano, Fabrizio; Guirguis, Amira (2024-01-12)Introduction: The designer benzodiazepine (DBZD) market continues to expand whilst evading regulatory controls. The widespread adoption of social media by pro-drug use communities encourages positive discussions around ... -
The benzydamine experience: A systematic review of Benzydamine abuse
Chiappini, Stephania; Miuli, Andrea; Mosca, Alessio; Pettorruso, Mauro; Guirguis, Amira; Corkery, John Martin; Martinotti, Giovanni; di Giannantonio, Massimo; Schifano, Fabrizio (2021-01-13)Background: Both prescription and over-the-counter (OTC) drugs recently emerged among novel psychoactive substances (NPS) being reported as ingested for recreational purposes. Among them, benzydamine (BZY), normally ... -
Beyond the Purple Drank. Study of promethazine abuse according to the European Medicines Agency (EMA) Adverse Drug Reactions (ADR) reports.
Chiappini, Stefania; Schifano, Fabrizio; Corkery, John Martin; Guirguis, Amira (2021-01-10)Background: Promethazine is a medicinal product, available on its own or in combination with other ingredients including dextromethorphan, paracetamol, and/or expectorants. Anecdotal reports have however indicated that ... -
Bicyclic 6-6 Systems: Pteridines
Rossiter, Sharon; Ostovar, Mehrnoosh (Elsevier, 2022)This article describes the literature on pteridines, covering the period from 2008 to 2020. The physical properties and reactions include photochemistry, substitution at ring nitrogens, nucleophilic substitution at ring ... -
The bridge between classical and ‘synthetic’/chemical psychoses: towards a clinical, psychopathological and therapeutic perspective
Orsolini, Laura; Chiappini, Stephania; Papanti, Duccio; De Berardis, Domenico; Corkery, John Martin; Schifano, Fabrizio (2019-11-20)The critical spread and dissemination of novel psychoactive substances (NPS), particularly among the most vulnerable youngsters, may pose a further concern about the psychotic trajectories related to the intake of new ... -
Buvidal: is it really a ‘game changer’ in the treatment of problematic opioid use?
Holloway, Kate; Schifano, Fabrizio (2023-11-30) -
Can mobile phone technology support a rapid sharing of information on Novel Psychoactive Substances among health and other professionals internationally?
Simonato, Pierluigi; Bersani, Francesco Saverio; Santacroce, Rita; Cinosi, Eduardo; Schifano, Fabrizio; Bersani, Giuseppe; Martinotti, Giovanni; Corazza, Ornella (2017-06-28)Background The diffusion of Novel Psychoactive Substances (NPSs), combined with the ability of the Internet to act as an online marketplace, has led to unprecedented challenges for governments, health agencies, and substance ... -
Cannabidiol (CBD) Use in Psychiatric Disorders; A Systematic Review
Bonaccorso, Stefania; Ricciardi, Angelo; Zangani, Caroline; Chiappini, Stefania; Schifano, Fabrizio (2019-09)Cannabidiol (CBD) and ∆9-tetrahydrocannabinol (THC) are the most represented phytocannabinoids in Cannabis sativa plants. However, CBD may present with a different activity compared with the psychotomimetic THC. Most ... -
Cannabis; epidemiological, neurobiological and psychopathological issues: an update
De Luca, Maria Antonietta; Di Chiara, Gaetano; Cadoni, Cristina; Lecca, Daniele; Orsolini, Laura; Papanti, Duccio; Corkery, John; Schifano, Fabrizio (2017-04-13)Cannabis is the illicit drug with both the largest current levels of consumption and the highest reported lifetime prevalence levels in the world. Across different countries, the prevalence of cannabis use varies according ... -
Captagon: Use and Trade in the Middle East
Al-Imam, Ahmed; Santacroce, Rita; Roman-Urrestarazu, Andres; Chilcott, Robert; Martinotti, G.; Bersani, Giuseppe; Corazza, Ornella (2017-05-31)Fenetheylline, a psychostimulant drug, often branded as Captagon, is a combination of amphetamine and theophylline. Since the cessation of its legal production in 1986, counterfeited products have been produced illicitly ... -
Carfentanil on the darknet : Potential scam or alarming public health threat?
Negri, Attilio; Townshend, Honor; McSweeney, Tim; Angelopoulou, Olga; Prilutskaya, Mariya; Bowden-Jones, Owen; Corazza, Ornella (2021-05)Background: In an age of global insecurity, highly potent synthetic drugs have become a major public health issue. Their online advertisement and sale are facilitated by surface web, darknet markets and social media fuelling ... -
A cellulose-based bioassay for the colorimetric detection of pathogen DNA
Saikrishnan, Deepika; Goyal, Madhu; Rossiter, Sharon; Kukol, A. (2014-12-01)Cellulose-paper-based colorimetric bioassays may be used at the point of sampling without sophisticated equipment. This study reports the development of a colorimetric bioassay based on cellulose that can detect pathogen ... -
Changing Trends in the Use of Kratom (Mitragyna speciosa) in Southeast Asia
Singh, D; Narayanan, S; Vicknasingam, B; Corazza, Ornella; Santacroce, Rita; Roman-Urrestarazu, Andres (2017-06-28)Objective: Kratom (Mitragyna speciosa. Korth) is an indigenous medicinal plant of Southeast Asia. This review paper aims to describe the trends of kratom use in Southeast Asia, particularly, in Malaysia and Thailand, where ... -
Characterisation of chemical composition and structural features of novel antimicrobial nanoparticles
Ren, Guogang; Calvo-Castro, Jesus; Ciric, Lena; Edirisinghe, Mohan; Cloutman-Green, Elaine; Illangakoon, Upulitha Eranka; Kang, Qiang; Mahalingam, Suntharavathanan; Matharu, Rupy Kaur; Wilson, Rory M; Cheong, Yuen Ki (2017-06-23)Three antimicrobial nanoparticle types (AMNP0, AMNP1 and AMNP2) produced using the TesimaTM thermal plasma technology were investigated and their compositions determined using a combination of analytical methods. Scanning ... -
Characteristics of deaths associated with kratom use
Corkery, John; Streete, Peter; Claridge, Hugh; Goodair, Christine; Papanti, Duccio G.; Orsolini, Laura; Schifano, Fabrizio; Sikka, Kanav; Körber, Sophie; Hendricks, Amy (2019-09-01)Background: Kratom (Mitragyna speciosa Korth) use has increased in Western countries, with a rising number of associated deaths. There is growing debate about the involvement of kratom in these events. Aims: This study ... -
The characteristics of deaths involving kratom in the United Kingdom and elsewhere
Corkery, John; Claridge, Hugh; Goodair, Christine; Papanti, Duccio; Orsolini, Laura; Koerber, Sophie; Schifano, Fabrizio (2016-05-31) -
The clinical challenges of synthetic cathinones
Schifano, Fabrizio; Napoletano, Flavia; Arillotta, Davide; Zangani, Caroline; Gilgar, Liam; Guirguis, Amira; Corkery, John; Vento, Alessandro (2019-11-01)Within the new psychoactive substances (NPS) scenario, several hundreds of different molecules, mostly including synthetic cannabinoids and cathinones, have so far been identified. The aims of the paper were to: (a) identify ... -
Clinical Implications of Kratom (Mitragyna speciosa) Use: a Literature Review
Prevete, Elisabeth; Kuypers, Kim Paula Colette; Theunissen, Eef Lien; Esposito, Gianluca; Ramaekers, Johannes Gerardus; Pasquini, Massimo; Corazza, Ornella (2023-06-30)Purpose of Review: This work aims to provide an up-to-date review of the preclinical and clinical scientific literature on the therapeutic value of kratom to better understand the underlying mechanisms related to its use ... -
Clozapine, neutropenia and Covid-19: should clinicians be concerned? 3 months report
Bonaccorso, Stefania; Ricciardi, Angelo; Ouabbou, Sophie; Theleritis, Christos; Ross-Michealides, Arabella; Metastasio, Antonio; Stewart, Neil; Mohammed, Marwa; Schifano, Fabrizio (2021-05)Background: Clozapine is among the most effective antipsychotics used for treatment resistant schizophrenia. Adverse reactions to clozapine include neutropenia. In March 2020, at the start of the Coronavirus -19 pandemic, ...