Browsing Research publications by Author "Annett, L.E."
Now showing items 1-9 of 9
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Behavioural analysis of unilateral monoamine depletion in the marmoset
Annett, L.E.; Rogers, D.C.; Henandez, T.D.; Dunnett, S.B. (1992)Unilateral stereotaxic injections of 6-hydroxydopamine (6-OHDA) into the nigrostriatal bundle of marmosets (Callithrix jacchus) produced substantial losses of tyrosine hydroxylase immunoreactive neurons from the substantia ... -
Behavioural assessment of the effects of embryonic nigral grafts in marmosets with unilateral OHDA lesions of the nigrostriatal pathway
Annett, L.E.; Martel, F.L.; Rogers, D.C.; Ridley, R. M.; Baker, H. F.; Dunnett, S.B. (1994)Grafts of embryonic nigral tissue were made into the striatum of marmosets (Callithrix jacchus) which had previously received a unilateral 6-hydroxydopamine (6-OHDA) lesion of the nigrostriatal bundle. The grafts comprised ... -
Behavioural effects of subthalmic nucleus lesions in the hemiparkinsonian marmoset.(Callithrix jacchus)
Henderson, J.M.; Annett, L.E.; Torres, E.M.; Dunnett, S.B. (1998)Recent studies in non-human primates support a role for the subthalamic nucleus in the expression of parkinsonian symptomatology, and it has been proposed that subthalamic lesions may provide a surgical treatment for the ... -
A comparison of the behavioural effects of embryonic nigral grafts in the caudate nucleus and in the putamen of marmosets with unilateral 6-OHDA lesions
Annett, L.E.; Torres, E.M.; Ridley, R. M.; Baker, H. F.; Dunnett, S.B. (1995)The behaviour of marmosets with unilateral 6-hydroxydopamine lesions of the nigrostriatal bundle and grafts of embryonic mesencephalon in either the caudate nucleus or the putamen was compared with that of lesion-alone and ... -
Continuous low-level glial cell line-derived neurotrophic factor delivery using recombinant AAV vectors provides neuroprotection and induces behavioural recovery in a primate model of Parkinson's disease
Eslamboli, A.; Georgievska, B.; Ridley, R. M.; Baker, H. F.; Muzyczka, N.; Burger, C.; Mandel, R. J.; Annett, L.E.; Kirik, D. (2005) -
Nigrostriatal a-synucleinopathy induced by recombinant AAV vector-mediated overexpression of human a-synuclein: a new primate model of Parkinson's disease
Kirik, D.; Annett, L.E.; Burger, C.; Muzyczka, N.; Mandel, R. J.; Bjorklund, A. (2003) -
Recombinant adeno-associated viral vector (rAAV) delivery of GDNF provides anatomical and behavioural protection against 6-OHDA lesions in the common marmoset monkey (Callithrix jacchus)
Eslamboli, A.; Cummings, R. M.; Ridley, R. M.; Baker, H. F.; Muzyczka, N.; Burger, C.; Mandel, R. J.; Kirik, D.; Annett, L.E. (2003) -
Sensorimotor deficits in a unilateral intrastriatal 6-OHDA partial lesion model of Parkinson's Disease in marmoset monkeys
Eslamboli, A.; Baker, H. F.; Ridley, R. M.; Annett, L.E. (2003) -
Subthalamic nucleus lesions induce deficits as well as benefits in the hemiparkinsonian rat
Henderson, J.M.; Annett, L.E.; Ryan, L.; Chiang, W.; Hidaka, S.; Torres, E.M.; Dunnett, S.B. (1999)Lesions of the subthalamic nucleus can restore some imbalances in motor output of the basal ganglia induced by nigrostriatal dopamine depletion, and have been proposed as a potential therapy for Parkinson’s disease. Although ...