Browsing Research publications by Author "Ashcroft, Frances M"

Now showing items 1-3 of 3

    • Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells 

      Haythorne, Elizabeth; Rohm, Maria; van de Bunt, Martijn; Brereton, Melissa F; Tarasov, Andrei I; Blacker, Thomas S; Sachse, Gregor; Silva Dos Santos, Mariana; Terron Exposito, Raul; Davis, Simon; Baba, Otto; Fischer, Roman; Duchen, Michael R; Rorsman, Patrik; MacRae, James I; Ashcroft, Frances M (2019-06-06)
      Diabetes is a global health problem caused primarily by the inability of pancreatic β-cells to secrete adequate levels of insulin. The molecular mechanisms underlying the progressive failure of β-cells to respond to glucose ...

    • Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production 

      Knudsen, Jakob G; Hamilton, Alexander; Ramracheya, Reshma; Tarasov, Andrei I; Brereton, Melissa; Haythorne, Elizabeth; Chibalina, Margarita V; Spégel, Peter; Mulder, Hindrik; Zhang, Quan; Ashcroft, Frances M; Adam, Julie; Rorsman, Patrik (2019-02-05)
      Diabetes is a bihormonal disorder resulting from combined insulin and glucagon secretion defects. Mice lacking fumarase (Fh1) in their β cells (Fh1βKO mice) develop progressive hyperglycemia and dysregulated glucagon ...

    • Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion 

      Vergari, Elisa; Knudsen, Jakob G; Ramracheya, Reshma; Salehi, Albert; Zhang, Quan; Adam, Julie; Asterholm, Ingrid Wernstedt; Benrick, Anna; Briant, Linford J B; Chibalina, Margarita V; Gribble, Fiona M; Hamilton, Alexander; Hastoy, Benoit; Reimann, Frank; Rorsman, Nils J G; Spiliotis, Ioannis I; Tarasov, Andrei; Wu, Yanling; Ashcroft, Frances M; Rorsman, Patrik (2019-01-11)
      Hypoglycaemia (low plasma glucose) is a serious and potentially fatal complication of insulin-treated diabetes. In healthy individuals, hypoglycaemia triggers glucagon secretion, which restores normal plasma glucose levels ...