Browsing Research publications by Author "Braoudaki, Maria"
Now showing items 1-20 of 21
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Analysis of SIGLEC12 expression, IMMUNOMODULATION and prognostic value in RENAL cancer using multiomic databases
Ogbodo, Amobichukwu K.; Mustafov, Denis; Arora, Mohit; Lambrou, George I.; Braoudaki, Maria; Siddiqui, Shoib (2024-01-30)Siglecs belong to a family of immune regulatory receptors predominantly found on hematopoietic cells. They interact with Sia, resulting in the activation or inhibition of the immune response. Previous reports have suggested ... -
Bioinformatics and Regression Analyses Manifest Tumor-Specific miRNA Expression Dynamics in Pediatric Embryonal Malignancies
Braoudaki, Maria; Koutsouris, Dimitrios-Dionysios; Kouris, Ioannis; Paidi, Anna; Koutsouri, Georgia; George Lambrou, I (Institute of Electrical and Electronics Engineers (IEEE), 2018-10-29)Pediatric Central Nervous System (CNS) neoplasms are the second most prevalent tumors of childhood. Further on, prognosis of this type of neoplasms still remain poor and the comprehension of the etiology and pathogenesis ... -
Box–Behnken design of thermo-responsive nano-liposomes loaded with a platinum( iv ) anticancer complex: evaluation of cytotoxicity and apoptotic pathways in triple negative breast cancer cells †
Sedky, Nada K.; Braoudaki, Maria; Mahdy, Noha Khalil; Amin, Kenzy; Fawzy, Iten M.; Efthimiadou, Eleni K.; Youness, Rana A.; Fahmy, Sherif Ashraf (2023-09-15)Herein, thermo-responsive liposomes (TLs) loaded with Asp (Asp/TLs) were produced by self-assembling DPPC, DSPE-PEG2000, and cholesterol. The preparation variables were optimized using the Box–Behnken design (BBD). The ... -
Chemokines and chemokine receptors in colorectal cancer; multifarious roles and clinical impact
Braoudaki, Maria; Ahmad, Mohammed Saqif; Mustafov, Denis; Seriah, Sara; Siddiqui, Mohammad Naseem; Siddiqui, Shoib (2022-10-13)Colorectal cancer (CRC) is considered the second cause of cancer death worldwide. The early diagnosis plays a key role in patient prognosis and subsequently overall survival. Similar to several types of cancer, colorectal ... -
Circular RNAs: New layer of complexity evading breast cancer heterogeneity
Dawoud, Alyaa; Zakaria, Zeina Ihab; Rashwan, Hannah Hisham; Braoudaki, Maria; Youness, Rana A. (2023-03-30)Advances in high-throughput sequencing techniques and bioinformatic analysis have refuted the "junk" RNA hypothesis that was claimed against non-coding RNAs (ncRNAs). Circular RNAs (circRNAs); a class of single-stranded ... -
Co-Deregulated miRNA Signatures in Childhood Central Nervous System Tumors: In Search for Common Tumor miRNA-Related Mechanics
Lambrou, George I.; Zaravinos, Apostolos; Braoudaki, Maria (2021-06-17)Despite extensive experimentation on pediatric tumors of the central nervous system (CNS), related to both prognosis, diagnosis and treatment, the understanding of pathogenesis and etiology of the disease remains scarce. ... -
Deciphering the Role of microRNA Mediated Regulation of Coronin 1C in Glioblastoma Development and Metastasis
Mustafov, Denis; Karteris, Emmanouil; Braoudaki, Maria (2023-01-04)Glioblastoma multiforme (GBM) is a highly heterogenic and malignant brain tumour with a median survival of 15 months. The initial identification of primary glioblastomas is often challenging. Coronin 1C (CORO1C) is a key ... -
Differential and Common Signatures of miRNA Expression and Methylation in Childhood Central Nervous System Malignancies: An Experimental and Computational Approach
Lambrou, George I.; Poulou, Myrto; Giannikou, Krinio; Themistocleous, Marios; Zaravinos, Apostolos; Braoudaki, Maria (2021-10-31)Epigenetic modifications are considered of utmost significance for tumor ontogenesis and progression. Especially, it has been found that miRNA expression, as well as DNA methylation plays a significant role in central ... -
Dysregulated placental microRNAs in Early and Late onset Preeclampsia
Lykoudi, Alexandra; Kolialexi, Aggeliki; Lambrou, George I; Braoudaki, Maria; Siristatidis, Charalampos; Papaioanou, George Konstantinos; Tzetis, Maria; Mavrou, Ariadni; Papantoniou, Nikolas (2018-01-01)INTRODUCTION: To determine the miRNA expression profile in placentas complicated by Preeclampsia (PE) and compare it to uncomplicated pregnancies. METHODS: Sixteen placentas from women with PE, [11 with early onset PE ... -
Editorial: Recent breakthroughs in the decoding of circulating nucleic acids and their applications to human diseases
El-Daly, Sherien M.; Talaat, Roba M.; Braoudaki, Maria; Youness, Rana A.; Cho, William C. (2023-05-10) -
In Silico and In Vitro Mapping of Receptor-Type Protein Tyrosine Phosphatase Receptor Type D in Health and Disease: Implications for Asprosin Signalling in Endometrial Cancer and Neuroblastoma
Orton, Sophie; Karkia, Rebecca; Mustafov, Denis; Gharanei, Seley; Braoudaki, Maria; Filipe, Alice; Panfilov, Suzana; Saravi, Sayeh; Khan, Nabeel; Kyrou, Ioannis; Karteris, Emmanouil; Chatterjee, Jayanta; Randeva, Harpal S. (2024-01-30)Background: Protein Tyrosine Phosphatase Receptor Type D (PTPRD) is involved in the regulation of cell growth, differentiation, and oncogenic transformation, as well as in brain development. PTPRD also mediates the effects ... -
MicroRNA expression profiles in pediatric dysembryoplastic neuroepithelial tumors.
Braoudaki, Maria; Lambrou; Papadodima; Stefanaki; Prodromou; Kanavakis (2016-01-30)Among noncoding RNAs, microRNAs (miRNAs) have been most extensively studied, and their biology has repeatedly been proven critical for central nervous system pathological conditions. The diagnostic value of several miRNAs ... -
Molecular Engines, Therapeutic Targets, and Challenges in Pediatric Brain Tumors: A Special Emphasis on Hydrogen Sulfide and RNA-Based Nano-Delivery
Fahmy, Sherif Ashraf; Dawoud, Alyaa; Zeinelabdeen, Yousra Ahmed; Kiriacos, Caroline Joseph; Daniel, Kerolos Ashraf; Eltahtawy, Omar; Abdelhalim, Miriam Mokhtar; Braoudaki, Maria; Youness, Rana A. (2022-10-26)Pediatric primary brain tumors represent a real challenge in the oncology arena. Besides the psychosocial burden, brain tumors are considered one of the most difficult-to-treat malignancies due to their sophisticated ... -
MYCN in Neuroblastoma: “Old Wine into New Wineskins”
Braoudaki, Maria; Hatziagapiou, Kyriaki; Zaravinos, Apostolos; Lambrou, George I. (2021-10-29)MYCN Proto-Oncogene, BHLH Transcription Factor (MYCN) has been one of the most studied genes in neuroblastoma. It is known for its oncogenetic mechanisms, as well as its role in the prognosis of the disease and it is ... -
A Novel Epigenetic Strategy to Concurrently Block Immune Checkpoints PD-1/PD-L1 and CD155/TIGIT in Hepatocellular Carcinoma
Assal, Reem A.; Elemam, Noha M.; Mekky, Radwa Y.; Attia, Abdelrahman A.; Soliman, Aya Hesham; Gomaa, Asmaa Ibrahim; Efthimiadou, Eleni K.; Braoudaki, Maria; Fahmy, Sherif Ashraf; Youness, Rana A. (2024-04-17)Tumor microenvironment is an intricate web of stromal and immune cells creating an immune suppressive cordon around the tumor. In hepatocellular carcinoma (HCC), Tumor microenvironment is a formidable barrier towards novel ... -
Novel Siglec-15-Sia axis inhibitor leads to colorectal cancer cell death by targeting miR-6715b-3p and oncogenes
Ahmad, Mohammed Saqif; Braoudaki, Maria; Patel, Hershna; Ahmad, Irshad; Waseem, Shagufta; Siddiqui, Shoib (2023-10-06)Siglecs are well known immunotherapeutic targets in cancer. Current checkpoint inhibitors have exhibited limited efficacy, prompting a need for novel therapeutics for targets such as Siglec-15. Presently, small molecule ... -
Oral Delivery of Psoralidin by Mucoadhesive Surface-Modified Bilosomes Showed Boosted Apoptotic and Necrotic Effects against Breast and Lung Cancer Cells
Youness, Rana Ahmed; Al-Mahallawi, Abdulaziz Mohsen; Mahmoud, Farah Haytham; Atta, Hind; Braoudaki, Maria; Fahmy, Sherif Ashraf (2023-03-15)This study aims to design and optimize chitosan-coated bilosomal formulations loaded with psoralidin (Ps-CS/BLs) with improved physicochemical properties, oral bioavailability, and boosted apoptotic and necrotic effects. ... -
Pharmacogenomic and epigenomic approaches to untangle the enigma of IL-10 blockade in oncology
Elemam, Noha M.; Mekky, Radwa Y.; Rashid, Gowhar; Braoudaki, Maria; Youness, Rana A. (2024-01-08)The host immune system status remains an unresolved mystery among several malignancies. An immune-compromised state or smart immune-surveillance tactics orchestrated by cancer cells are the primary cause of cancer invasion ... -
Post-Operative Thoracic Epidural Analgesia and Incidence of Major Complications according to Specific Safety Standardized Documentation: A Large Retrospective Dual Center Experience
Sarridou, Despoina G; Mouratoglou, Sophia Anastasia; Mitchell, Jeremy; Cox, Felicia; Boutou, Afroditi; Braoudaki, Maria; Lambrou, George; Konstantinidou, Maria; Argyriadou, Heklena; Walker, Christopher (2023-11-29)(1) Background: Thoracic epidural analgesia is considered the gold standard in post-operative pain management following thoracic surgery. This study was designed to explore the safety of thoracic epidural analgesia and to ... -
Serum microRNA array analysis identifies miR-140-3p, miR-33b-3p and miR-671-3p as potential osteoarthritis biomarkers involved in metabolic processes.
Ntoumou, Eleni; Tzetis, Maria; Braoudaki, Maria; Lambrou, George; Poulou, Myrto; Malizos, Konstantinos; Stefanou, Nikolaos; Anastasopoulou, L; Tsezou, Aspasia (2017-12-12)Background: MicroRNAs (miRNAs) in circulation have emerged as promising biomarkers. In this study, we aimed to identify a circulating miRNA signature for osteoarthritis (OA) patients and in combination with bioinformatics ...