Browsing Research publications by Author "Brocchini, S."
Now showing items 1-6 of 6
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Aconityl-derived polymers for biomedical applications : Modeling study of cis-trans isomerisation
Zloh, Mire; Dinand, E.; Brocchini, S. (2003-05-01)Soluble polymers have been prepared that are designed to undergo enhanced rates of hydrolysis at pH values less than that observed in blood circulation. The degradable element in the polymer mainchain is derived from ... -
Identification and insertion of 3-carbon bridges in protein disulfide bonds : A computational approach
Zloh, Mire; Shaunak, S.; Balan, S.; Brocchini, S. (2007-05-01)More than 42,000 3D structures of proteins are available on the Internet. We have shown that the chemical insertion of a 3-carbon bridge across the native disulfide bond of a protein or peptide can enable the site-specific ... -
Molecular dynamics simulations of proteins with chemically modified disulfide bonds
Godwin, A.; Pedone, E.; Balan, S.; Jumnah, R.; Brocchini, S.; Choi, J.-W.; Shaunak, S.; Zloh, Mire (2007-02)Proteins that are used as therapeutic drugs act in the extracellular microenvironment. They usually have a small number of intramolecular disulfide bonds to help maintain their tertiary structure in the vascular circulation. ... -
Partially glycosylated dendrimers block MD-2 and prevent TLR4-MD-2-LPS complex mediated cytokine responses
Barata, T.S.; Brocchini, S.; Teo, I.; Zloh, Mire; Shaunak, S. (2011-06-01)The crystal structure of the TLR4-MD-2-LPS complex responsible for triggering powerful pro-inflammatory cytokine responses has recently become available. Central to cell surface complex formation is binding of lipopolysaccharide ... -
Site-specific PEGylation of protein bisulfide bonds using a three-carbon bridge
Balan, S.; Godwin, A.; Laborde, C.M.; Brocchini, S.; Choi, J.-W.; Teo, I.; Shaunak, S.; Heidelberger, S.; Zloh, Mire (2007)The covalent conjugation of a functionalized poly(ethylene glycol) (PEG) to multiple nucleophilic amine residues results in a heterogeneous mixture of PEG positional isomers. Their physicochemical, biological, and ... -
Structural studies of biologically active glycosylated polyamidoamine (PAMAM) dendrimers
Barata, T.S.; Teo, I.; Shaunak, S.; Zloh, Mire; Brocchini, S. (2011-08-01)The partial modification of carboxylic acid terminated polyamidoamine (PAMAM) dendrimers with glucosamine has been reported to give dendrimer glucosamine conjugates novel immuno-modulatory and anti-angiogenic properties. ...