Browsing Research publications by Author "Cook, Michael"
Now showing items 1-10 of 10
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Branched Copolymer Surfactants as Versatile Templates for Responsive Emulsifiers with Bespoke Temperature‐Triggered Emulsion‐Breaking or Gelation
Rajbanshi, Abhishek; Alves da Silva, Marcelo; Haslett, Niamh; Cranwell, Philippa; Cunningham, Neil; Mahmoudi, Najet; Murnane, Darragh; Pavlova, Ewa; Slouf, Miroslav; Dreiss, Cecile; Cook, Michael (2023-10-27)It has been found that the thermoresponsive behavior of emulsions stabilized by block copolymer surfactants (BCSs) can induce either gelation or emulsion break‐up with mild temperature changes. A hydrophilic, steric‐stabilizing ... -
Development of an immobilization system for in situ micronutrients release
Cook, Michael (2016-12-31)An immobilization system constituted by coated microcapsules was developed aiming at immobilizing probiotic bacteria capable of producing folate and release it in a sustained manner into the intestine. Despite no probiotic ... -
Diffusion through the ex vivo vitreal body - bovine, porcine, and ovine models are poor surrogates for the human vitreous
Shafaie, Sara; Hutter, Victoria; Brown, Marc; Cook, Michael; Chau, David (2018-10-25)The human vitreous humour is a complex gel structure whose composition and physical properties can vary considerably from person to person and also change with age. To date, the viscoelastic properties of the human vitreous ... -
Influence of surface geometry on the culture of human cell lines: a comparative study using flat, round-bottom and v-shaped 96 well plates
Shafaie, Sara; Hutter, Victoria; Brown, Marc; Cook, Michael; Chau, David (2017-10-30)In vitro cell based models have been invaluable tools for studying cell behaviour and for investigating drug disposition, toxicity and potential adverse effects of administered drugs. Within this drug discovery pipeline, ... -
Modifying the Properties of Thermogelling Poloxamer 407 Solutions through Covalent Modification and the Use of Polymer Additives
Abou Shamat, Mohamad; Calvo-Castro, Jesus; Stair, Jacqueline; Cook, Michael (2019-07-22)Thermoresponsive polymers that undergo sol–gel transition in a physiological temperature range have applications in biomedical science. Poloxamer 407 (P407) is commonly used as thermogelling material and has been approved ... -
A mucosa-mimetic material for the mucoadhesion testing of thermogelling semi-solids
Cook, Michael (2017-08-07)Mucosa-mimetic materials are synthetic substrates which aim to replace animal tissue in mucoadhesion experiments. One potential mucosa-mimetic material is a hydrogel comprised of N-acryloyl-d-glucosamine and 2-hydroxyeth ... -
Mucosa-mimetic materials to replace animal tissue in mucoadhesion research
Cook, Michael (2016)Pharmaceutical scientists often wish to design dosage forms which adhere to mucosal membranes to provide a localised effect. These “mucoadhesive” formulations are typically evaluated using ex vivo animal tissue, a large ... -
Polymeric gels for intravaginal drug delivery
Cook, Michael; Brown, Marc (2018-01-28)Intravaginal drug delivery can elicit a local effect, or deliver drugs systemically without hepatic first pass metabolism. There are a number of emerging areas in intravaginal drug delivery, but the vagina is a challenging ... -
Soluplus solutions as thermothickening materials for topical drug delivery.
Cook, Michael; Abou Shamat, Mohamad (2019-01-05)Soluplus is a pharmaceutical excipient used primarily in the manufacture of solid dispersions. The polymer also exhibits interesting rheology in aqueous solution, increasing in viscosity as the solution is warmed. This ... -
Synthesis and solution properties of a temperature-responsive PNIPAM–b-PDMS–b-PNIPAM triblock copolymer
Cook, Michael; Filippov, Sergey K; Khutoryanskiy, Vitaliy V. (2017-08-31)In this paper, we report the synthesis and self-assembly of a novel thermoresponsive PNIPAM60–b-PDMS70–b-PNIPAM60 triblock copolymer in aqueous solution. The copolymer used a commercially available precursor modified with ...