Browsing Research publications by Author "Godwin, Antony"

Now showing items 1-4 of 4

    • Disulfide bridge based PEGylation of proteins 

      Brocchini, Steve; Godwin, Antony; Balan, Sibu; Choi, Ji-won; Zloh, Mire; Shaunak, Sunil (2008-01)
      PEGylation is a clinically proven strategy for increasing the therapeutic efficacy of protein-based medicines. Our approach to site-specific PEGylation exploits the thiol selective chemistry of the two cysteine sulfur atoms ...

    • PEGylation of native disulfide bonds in proteins 

      Brocchini, Steve; Balan, Sibu; Godwin, Antony; Choi, Ji-Won; Zloh, Mire; Shaunak, Sunil (2006)
      PEGylation has turned proteins into important new biopharmaceuticals. The fundamental problems with the existing approaches to PEGylation are inefficient conjugation and the formation of heterogeneous mixtures. This is ...

    • Site-specific PEGylation at histidine tags 

      Cong, Yuehua; Pawlisz, Estera; Bryant, Penny; Balan, Sibu; Laurine, Emmanuelle; Tommasi, Rita; Singh, Ruchi; Dubey, Sitara; Peciak, Karolina; Bird, Matthew; Sivasankar, Amrita; Swierkosz, Julia; Muroni, Maurizio; Heidelberger, Sibylle; Farys, Monika; Khayrzad, Farzad; Edwards, Jeff; Badescu, George; Hodgson, Ian; Heise, Charles; Somavarapu, Satyanarayana; Liddell, John; Powell, Keith; Zloh, Mire; Choi, Ji-won; Godwin, Antony; Brocchini, Steve (2012)
      The efficacy of protein-based medicines can be compromised by their rapid clearance from the blood circulatory system. Achieving optimal pharmacokinetics is a key requirement for the successful development of safe protein-based ...

    • Site-specific PEGylation of native disulfide bonds in therapeutic proteins 

      Shaunak, Sunil; Godwin, Antony; Choi, Ji-Won; Balan, Sibu; Pedone, Elisa; Vijayarangam, Damotharan; Heidelberger, Sibylle; Teo, Ian; Zloh, Mire; Brocchini, Steve (2006)
      Native disulfide bonds in therapeutic proteins are crucial for tertiary structure and biological activity and are therefore considered unsuitable for chemical modification. We show that native disulfides in human interferon ...