Browsing Research publications by Author "Gorelik, Julia"

Now showing items 1-3 of 3

    • GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation 

      Shigeto, Makoto; Ramracheya, Reshma; Tarasov, Andrei I; Cha, Chae Young; Chibalina, Margarita V; Hastoy, Benoit; Philippaert, Koenraad; Reinbothe, Thomas; Rorsman, Nils; Salehi, Albert; Sones, William R; Vergari, Elisa; Weston, Cathryn; Gorelik, Julia; Katsura, Masashi; Nikolaev, Viacheslav O; Vennekens, Rudi; Zaccolo, Manuela; Galione, Antony; Johnson, Paul R V; Kaku, Kohei; Ladds, Graham; Rorsman, Patrik (2015-12-01)
      Strategies aimed at mimicking or enhancing the action of the incretin hormone glucagon-like peptide 1 (GLP-1) therapeutically improve glucose-stimulated insulin secretion (GSIS); however, it is not clear whether GLP-1 ...

    • Localized and non-contact mechanical stimulation of dorsal root ganglion sensory neurons using scanning ion conductance microscopy 

      Sánchez, Daniel; Anand, Uma; Gorelik, Julia; Benham, Christopher D; Bountra, Chas; Lab, Max; Klenerman, David; Birch, Rolfe; Anand, Praveen; Korchev, Yuri (2007)
      Mechanosensitive ion channels convert external mechanical force into electrical and chemical signals in cells, but their physiological function in different tissues is not clearly understood. One reason for this is that ...

    • Noncontact measurement of the local mechanical properties of living cells using pressure applied via a pipette 

      Sánchez, Daniel; Johnson, Nick; Li, Chao; Novak, Pavel; Rheinlaender, Johannes; Zhang, Yanjun; Anand, Uma; Anand, Praveen; Gorelik, Julia; Frolenkov, Gregory I; Benham, Christopher; Lab, Max; Ostanin, Victor P; Schäffer, Tilman E; Klenerman, David; Korchev, Yuri E (2008)
      Mechanosensitivity in living biological tissue is a study area of increasing importance, but investigative tools are often inadequate. We have developed a noncontact nanoscale method to apply quantified positive and negative ...