Browsing Research publications by Author "Groot, Pieter H E"
Now showing items 1-2 of 2
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Cloning, in vitro expression, and functional characterization of a novel human CC chemokine of the monocyte chemotactic protein (MCP) family (MCP-4) that binds and signals through the CC chemokine receptor 2B
Berkhout, Theo; Sarau, Henry M.; Moores, Kitty E.; White, John R.; Elshourbagy, Nabil; Appelbaum, Edward; Reape, Theresa J.; Brawner, Mary; Makwana, Jayneeta; Foley, James J.; Schmidt, Dulcie B.; Imburgia, Christine; McNulty, Dean; Matthews, Jane; O'Donnell, Kevin; O'Shannessy, Daniel; Scott, Miller; Groot, Pieter H E; Macphee, Colin H. (1997-06-27)Here we describe the characterization of a novel human CC chemokine, tentatively named monocyte chemotactic protein (MCP-4). This chemokine was detected by random sequencing of expressed sequence tags in cDNA libraries. ... -
SR-12813 lowers plasma cholesterol in beagle dogs by decreasing cholesterol biosynthesis
Berkhout, Theo; Simon, Helen M.; Jackson, Brian; Yates, John; Pearce, Nigel; Groot, Pieter H E; Bentzen, Craig; Niesor, Eric; Kerns, William D.; Suckling, Keith E. (1997-09-01)SR-12813 inhibits cholesterol biosynthesis in Hep G2 cells via an enhanced degradation of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. Here we also show that SR-12813 inhibits cholesterol biosynthesis in vivo. ...