Browsing Research publications by Author "Health Services Research group"
Now showing items 1-16 of 16
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18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in the Assessment of Occult Primary Head and Neck Cancers : An Audit and Review of Published Studies
Wong, W.L.; Sonoda, L.I.; Gharpurhy, A.; Gollub, F.; Wellsted, D.; Goodchild, K.; Lemon, C.; Saunders, M.; Farrell, R. (2012-04)Aims: To assess the value of 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with squamous cell and undifferentiated cancer neck nodes and no primary site on conventional ... -
An association between depressive symptoms and survival in incident dialysis patients
Chilcot, Joseph; Davenport, Andrew; Wellsted, D.; Firth, John; Farrington, Ken (2011)Depression in end-stage renal disease patients is detrimental to quality of life, and is also associated with adverse clinical outcomes. The aim of this study was to examine whether depression symptoms in 'incident dialysis' ... -
Can simvastatin improve erectile function and health-related quality of life in men aged over 40 years with erectile dysfunction? : Rationale and design of the Erectile Dysfunction and Statins (EDS) Trial [ISRCTN66772971]
Trivedi, Daksha; Kirby, Michael; Norman, Felicity; Przybytniak, Izabela; Ali, Shehzad; Wellsted, D. (2011-12-01)OBJECTIVE To describe the rationale and design of the Erectile Dysfunction and Statins (EDS) Trial which aims to evaluate the effectiveness of simvastatin on erectile function and health-related quality of life in men aged ... -
Can simvastatin improve erectile function and health-related quality of life in men aged ≥40 years with erectile dysfunction? : Results of the Erectile Dysfunction and Statins Trial [ISRCTN66772971]
Trivedi, Daksha; Kirby, Michael; Wellsted, D.; Ali, Shehzad; Hackett, Geoff; O'Connor, Bernadette; Van Os, Sandra (2013-01-29)To evaluate the effectiveness and cost-effectiveness of simvastatin on erectile function and health-related quality of life in men aged ≥40 years with erectile dysfunction (ED). -
Can simvastatin improve erectile function and quality of life in men with erectile dysfunction?
Trivedi, Daksha; Kirby, Michael; Norman, Felicity; Przybytniak, Izabela; Ali, Shehzad; Wellsted, D. (2011) -
Choosing Not to Take Phosphate Binders : The Role of Dialysis Patients' Medication Beliefs
Wileman, Vari; Chilcot, Joseph; Norton, Sam; Hughes, Lyndsay; Wellsted, D.; Farrington, Ken (2011)Objective: Patients with end-stage renal disease (ESRD) receiving haemodialysis are at risk of cardiovascular disease and bone disorders related to high levels of serum phosphate (PO(4)). Phosphate binders are an important ... -
Distinct Depression Symptom Trajectories over the First Year of Dialysis : Associations with Illness Perceptions
Chilcot, Joseph; Norton, Sam; Wellsted, D.; Davenport, Andrew; Firth, John; Farrington, Ken (2013-02)BACKGROUND: Depression in the dialysis population is common, but trajectories of depression symptoms are unknown. PURPOSE: This study aims to (1) examine whether different patterns of depression symptoms exist over the ... -
Does antifungal prophylaxis with daily oral fluconazole reduce the risk of fungal peritonitis in peritoneal dialysis patients? The Pan Thames Renal Audit
Davenport, Andrew; Wellsted, D.; Pan Thames Renal Audit Peritoneal (2011)Background and Objectives: Fungal peritonitis increases the risk of transfer to haemodialysis and mortality. Methods: We audited the effect of co-prescription of daily oral fluconazole with antibiotics in the Pan Thames ... -
Effect of magnesium supplementation on blood pressure : a meta-analysis
Kass, Lindsy; Weekes, J.; Carpenter, Lewis (2012)To date, there has been inconclusive evidence regarding the effect of magnesium supplements on blood pressure (BP). This meta-analysis was conducted to assess the effect of magnesium supplementation on BP and to establish ... -
The factor structure of the revised illness perception questionnaire (IPQ-R) in end-stage renal disease patients
Chilcot, Joseph; Norton, Sam; Wellsted, D.; Farrington, Ken (2012)The purpose of this study was to examine the factor structure of the Revised Illness Perceptions Questionnaire (IPQ-R) in a sample of 374 end-stage renal disease (ESRD) patients. A confirmatory factor analysis of the IPQ-R, ... -
Identifying depression in South Asian patients with end-stage renal disease : Considerations for practice
Sharma, Shivani; Bhui, Kamaldeep; Chilcot, Joseph; Wellsted, D.; Farrington, Ken (2011-12)Depression is a prevalent burden for patients with end-stage renal disease (ESRD) and one that is under-recognized and consequently under-treated. Although several studies have explored the association between depression ... -
Illness representations and concurrent depression symptoms in haemodialysis patients
Chilcot, Joseph; Wellsted, D.; Davenport, Andrew; Farrington, Ken (2011)We examined the association between illness perceptions and depression symptoms in established haemodialysis patients (HD). Two hundred and fifteen patients completed the Revised Illness Perception Questionnaire and the ... -
Perfusion CT assessment of the colon and rectum : Feasibility of quantification of bowel wall perfusion and vascularization
Khan, Sairah; Goh, Vicky; Tam, Emily; Wellsted, D.; Halligan, Steve (2012)The aim was to determine the feasibility of vascular quantification of the bowel wall for different anatomical segments of the colorectum. Following institutional ethical approval and informed consent, 39 patients with ... -
Quality of Life and Survival in Patients with Advanced Kidney Failure Managed Conservatively or by Dialysis
Da Silva-Gane, Maria; Wellsted, D.; Greenshields, Hannah; Norton, Sam; Chandna, Shahid M.; Farrington, Ken (2012-12-07)BACKGROUND AND OBJECTIVES: Benefits of dialysis in elderly dependent patients are not clearcut. Some patients forego dialysis, opting for conservative kidney management (CKM). This study prospectively compared quality of ... -
Relationship between human tumour angiogenic profile and combretastatin-induced vascular shutdown : an exploratory study
Gaya, A.M.; Daley, F.; Taylor, N. J.; Tozer, G.; Qureshi, U; Padhani, A.; Pedley, R. Barbara; Begent, R; Wellsted, D.; Stirling, J J; Rustin, G (2008)Combretastatin-A4-phosphate (CA4P) acts most effectively against immature tumour vasculature. We investigated whether histological angiogenic profile can explain the differential sensitivity of human tumours to CA4P, by ... -
Use of high-intensity statin therapy with simvastatin 80 mg and atorvastatin 80 mg in primary care
Meek, C.L.; Reston, J.; Ramsbottom, T.; Pathmanathan, H.; Viljoen, A. (2011)Aims: Cardiovascular disease (CVD) is the most common cause of death worldwide. Pharmaceutical risk reduction with high-intensity statin therapy is advisable for high-risk patients. Clinicians face a conflict between ...