Browsing Research publications by Author "Kirton, S. B."

Now showing items 1-3 of 3

    • Comparative modelling of cytochromes P450 

      Kirton, S. B.; Baxter, C. A.; Sutcliffe, M. J. (2002-03-31)
      The superfamily of enzymes known as the cytochromes P450 (P450s) comprises a wide-ranging class of proteins with diverse functions. They are known, amongst other things, to be involved in the hormonal regulation of metabolism ...

    • In silico methods for predicting ligand binding determinants of cytochromes P450 

      de Groot, M. J.; Kirton, S. B.; Sutcliffe, M. J. (2004)
      A large number of computational methodologies have been used to predict, and thus help explain, the metabolism catalysed by the enzymes of the cytochrome P450 superfamily (P450s). A summary of the methodologies and resulting ...

    • Prediction of binding modes for ligands in the cytochromes p450 and other heme-containing proteins 

      Kirton, S. B.; Murray, C. W.; Verdonk, M. L.; Taylor, R. D. (2005-03-01)
      The cytochromes P450 (P450s) are a family of heme-containing monooxygenase enzymes involved in a variety of functions, including the metabolism of endogenous and exogenous substances in the human body. During lead optimization, ...