Browsing Research publications by Author "Lees, P."
Now showing items 1-11 of 11
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Flunixin pharmacokinetics and serum thromboxane inhibition in the dog
McKellar, Quintin; Galbraith, E. A.; Bogan, J. A.; Russell, C. S.; Hooke, R. E.; Lees, P. (1989)Flunixin meglumine administered orally to beagle dogs at doses of 0.55, 1.10 or 1.65 mg/kg bodyweight was rapidly absorbed to produce maximum mean plasma concentrations of 2.40 +/- 0.70, 4.57 +/- 1.12 and 7.42 +/- 2.07 ... -
Pharmacodynamics and pharmacokinetics of carprofen in the horse.
Lees, P.; McKellar, Quintin; May, S.A.; Ludwig, B. (1994-05)The pharmacokinetics and pharmacodynamics of the nonsteroidal anti-inflammatory drug (NSAID) carprofen have been evaluated in 6 horses using a model of acute non-immune inflammation. Following intravenous administration ... -
Pharmacodynamics and pharmacokinetics of tolfenamicacid in ruminating calves: Evaluation in models of acute inflammation
Lees, P.; McKellar, Quintin; Foot, R.; Gettinby, G. (1998-05)Injections of mild irritants intradermally (carrageenan, zymosan and dextran) and intracaveally (carrageenan)in a tissue cage model of inflammation were used in studies of the pharmacodynamics and pharmacokinetics of ... -
Pharmacodynamics of tolfenamic acid in dogs : Evaluation of dose response relationships
McKellar, Quintin; Lees, P.; Gettinby, G. (1994-03-03)Tolfenamic acid was administered to beagle dogs at 2, 4 and 8 mg/kg bodyweight i.m. and the concentration of drug in plasma and in inflamed (administered carrageenan) and non-inflamed subcutaneous tissue cage fluid was ... -
Pharmacokinetic and pharmacodynamic profiles of danofloxacin administered by two dosing regimens in calves infected with Mannheimia (Pasteurella) haemolytica
Sarasola, P.; Lees, P.; AliAbadi, F.S.; McKellar, Quintin; Donachie, W.; Marr, K.A.; Sunderland, S.J.; Rowan, T.G. (2002-09)The pharmacokinetics and pharmacodynamics of danofloxacin in calves with induced Mannheimia (Pasteurella) haemolytica pneumonia were evaluated. Calves received either saline as an intravenous (IV) bolus or danofloxacin ... -
Pharmacokinetics and pharmacodynamics of phenylbutazone and oxyphenbutazone in the donkey
Cheng, Z.; McKellar, Quintin; Nolan, A.; Lees, P. (1996-04) -
Pharmacokinetics, tolerance and serum thromboxane inhibition of carprofen in the dog
McKellar, Quintin; Pearson, T.; Bogan, J.A.; Gaibraith, E.A.; Lees, P.; Ludwig, B.; Tiberghien, M.P. (1990)The non-steroidal anti-inflammatory drug (NSAID) carprofen was administered to dogs as a mixed-micelle solution at a dose rate of 0–7 mg/kg intravenously, as a palatable paste at a dose rate of 0–7 mg/kg orally, and as an ... -
Pharmacology and therapeutics of non-steroidal anti-inflammatory drugs in the dog and cat 2 : Individual agents
McKellar, Quintin; May, S.A.; Lees, P. (1991)The general pharmacology of the non-steroidal anti-inflammatory drugs (NSAIDs) used in dogs and cats has been described in part 1 of this review (Lees and others 1991). This paper outlines the properties of the individual ... -
Pharmacology and therapeutics of nonsteroidal antiinflammatory drugs in the dog and cat 1 : General pharmacology
Lees, P.; May, S.A.; McKellar, Quintin (1991)The inflammatory process is described with particular reference to the cardinal signs, the microcir-culatory changes and the mediators and modulators of inflammation. Mediators and modulars comprise targets for therapeutic ... -
Preliminary pharmacokinetic and pharmacodynamic studies on flunixin meglumine in donkeys
Cheng, Z.; McKellar, Quintin; Nolan, A.; Lees, P. (1996) -
Stereospecific pharmacodynamics and pharmacokinetics of carprofen in the dog
McKellar, Quintin; Delatour, P.; Lees, P. (1994-12)The non-steroidal anti-inflammatory drug (NSAID) carprofen (CPF) contains a single chiral centre. It was administered orally to Beagle dogs as a racemate (rac-CPF) at a dose of 4 mg per kg body weight and as individual ...