Browsing Research publications by Author "Mackay, J.P."
Now showing items 1-4 of 4
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Dissection of the contributions toward dimerization of glycopeptide antibiotics
Mackay, J.P.; Gerhard, U.; Beauregard, D.A.; Maplestone, R.A.; Williams, D.H. (1994-06-01)A procedure for the determination of association constants in aqueous solution using hydrogen-deuterium exchange has been developed and used to measure the dimerization constant, K(dim), for a number of strongly dimerizing ... -
Glycopeptide antibiotic activity and the possible role of dimerization : A model for biological signaling
Mackay, J.P.; Gerhard, U.; Beauregard, D.A.; Westwell, M.S.; Searle, M.S.; Williams, D.H. (1994-06-01)It is demonstrated that the presence of bacterial cell wall analogues may either enhance or, in the case of ristocetin A, oppose dimerization of glycopeptide antibiotics. These observations may imply that dimerization plays ... -
The role of the sugar and chlorine substituents in the dimerization of vancomycin antibiotics
Gerhard, U.; Mackay, J.P.; Maplestone, R.A.; Williams, D.H. (1993-01-01) -
Toward an estimation of binding constants in aqueous solution : Studies of associations of vancomycin group antibiotics
Williams, D.H.; Searle, M.S.; Mackay, J.P.; Gerhard, U.; Maplestone, R.A. (1993-01-01)An approach toward the estimation of binding constants for organic molecules in aqueous solution is presented, based upon a partitioning of the free energy of binding. Consideration is given to polar and hydrophobic ...