Browsing Research publications by Author "Martin, Abigail"
Now showing items 1-2 of 2
-
Morphometric Characterization of Rat and Human Alveolar Macrophage Cell Models and their Response to Amiodarone using High Content Image Analysis
Hoffman, Ewelina; Bodhaniya, Aateka; Ball, Doug; Klapwijk, Jan; Millar, Val; Kumar, Abhinav; Martin, Abigail; Mahendran, Rhamiya; Dailey, Lea Ann; Forbes, Ben; Hutter, Victoria (2017-12-31)Purpose. Progress to the clinic may be delayed or prevented when vacuolated or “foamy” alveolar macrophages are observed during non-clinical inhalation toxicology assessment. The first step in developing methods to study ... -
Profiling alveolar macrophage responses to inhaled compounds using in vitro high content image analysis
Hoffman, Ewelina; Urbano, Laura; Martin, Abigail; Mahendran, Rhamiya; Patel, Aateka; Murnane, Darragh; Page, Clive; Dailey, Lea Ann; Forbes, Ben; Hutter, Victoria (2023-07-12)One of the main hurdles in the development of new inhaled medicines is the frequent observation of foamy macrophage (FM) responses in non-clinical studies in experimental animals, which raises safety concerns and hinders ...