Browsing Research publications by Author "Martin, G P"
Now showing items 1-7 of 7
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Biocompatible polymer blends : Effects of physical processing on the molecular interaction of poly(vinyl alcohol) and poly(vinyl pyrrolidone)
Jones, S. A.; Martin, G P; Royall, P.G.; Brown, Marc (2005-12-05)Blending is a very effective method for manufacturing new polymeric materials; however, the process used to combine two polymers can influence the physicochemical properties of the final product. As such, the aim of this ... -
Effect of heat on the percutaneous absorption and skin retention of three model penetrants
Akomeah, F; Nazir, T; Martin, G P; Brown, Marc (2004-02)The effect of heat on the transdermal delivery of model penetrants of differing lipophilicity through artificial membranes (non-rate limiting) and human epidermis was investigated in vitro. Saturated suspensions of the ... -
Effects of sucrose and trehalose on the preservation of the native structure of spray-dried lysozyme
Liao, Y H; Brown, Marc; Nazir, T.; Quader, A.; Martin, G P (2002)Purpose. To investigate the effects of sucrose, trehalose, sucrose/ dextran mixtures, and sucrose/ trehalose mixtures on the preservation of the native structure of spray- dried lysozyme in the solid state. Methods. The ... -
An in vitro study of the diclofenac delivery properties of hyaluronan in human skin
Martin, G P; Brown, Marc; Bennett, F C; Marriott, C. (1999)Previous in vitro studies have indicated that hyaluronan, when compared to buffer controls, effects a controlled and sustained release of diclofenac through the skin by the formation of a reservoir of the drug around the ... -
Manipulation of beclomethasone-hydrofluoroalkane interactions using biocompatible macromolecules
Jones, S. A.; Martin, G P; Brown, Marc (2006-05)The aim of this work was to physically stabilise beclomethasone dipropionate biocompatible polymers in order to allow the efficient delivery of the steroid to the airways from a pressurised metered dose inhaler (pMDI). BDP ... -
Triggered in situ drug supersaturation and hydrophilic matrix self-assembly
Benaouda, F; Brown, Marc; Martin, G P; Jones, S A (2012)To understand in situ drug thermodynamic activity when embedded in a supramolecular structured hydrophilic matrix that simultaneously self-assembled during drug supersaturation. -
Validation of a reverse-phase high performance liquid chromatographic method for concurrent assay of a weak base (salmeterol xinafoate) and a pharmacologically active steroid (fluticasone propionate)
Murnane, D; Martin, G P; Marriott, C (2006-03-18)The analysis of weakly basic drugs Such as salmeterol xinafoate (SX) by reverse-phase liquid chromatography remains a problem, particularly when present in combination with other drugs such as steroids and weak acids. This ...