Browsing Research publications by Author "O'Shaughnessy, K.M."
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The gain-of-function G389R variant of the β1-adrenoceptor does not influence blood pressure or heart rate response to β-blockade in hypertensive subjects
O'Shaughnessy, K.M.; Fu, B.; Dickerson, Claire; Thurston, D.; Brown, M.J. (2000)Mutation scanning of the b1-adrenoceptor gene has identified a polymorphism, G389R, that markedly affects G-protein coupling of the receptor and resulting cAMP production. We have investigated the effect of this functionally ...