Browsing Research publications by Author "Pance, Alena"
Now showing items 1-7 of 7
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Differential gene expression in cells with different p53 mutations identifies genome-wide p53 targets and shows distinct modulation of cellular pathways in response to DNA damage
Eror Barnes, Patricia; de la Concha, Maria Jose; Mwikali, Kioko; Ng, Bee Ling; Ponstingl, Hannes; Pance, Alena (BioRxiv, 2024-09-06)The fundamental transcription factor p53 regulates cellular processes and integrates signals of cellular stress, triggering a coordinated response to ensure survival of cells restored to healthy function and programmed ... -
Editorial: Stem cell technologies meet stem cell biology to shine new light into tropical infectious diseases
Pance, Alena; Rinaldi, Gabriel (2024-05-07) -
Extracellular vesicles could be a putative posttranscriptional regulatory mechanism that shapes intracellular RNA levels in Plasmodium falciparum
Kioko, Mwikali; Pance, Alena; Mwangi, Shaban; Goulding, David; Kemp, Alison; Rono, Martin; Ochola-Oyier, Lynette Isabella; Bull, Pete C.; Bejon, Philip; Rayner, Julian C.; Abdi, Abdirahman I. (2023-10-13)Plasmodium falciparum secretes extracellular vesicles (PfEVs) that contain parasite-derived RNA. However, the significance of the secreted RNA remains unexplored. Here, we compare secreted and intracellular RNA from asexual ... -
The mRNA content of plasma extracellular vesicles provides a window into molecular processes in the brain during cerebral malaria
Kioko, Mwikali; Mwangi, Shaban; Pance, Alena; Ochola-Oyier, Lynette Isabella; Kariuki, Symon; Newton, Charles; Bejon, Philip; Rayner, Julian C; Abdi, Abdirahman I (2024-08-16)The impact of cerebral malaria on the transcriptional profiles of cerebral tissues is difficult to study using noninvasive approaches. We isolated plasma extracellular vesicles (EVs) from patients with cerebral malaria and ... -
The mRNA content of plasma extracellular vesicles provides a window into the brain during cerebral malaria disease progression
Abdi, Abdirahman; Mwikali, Kioko; Mwangi, Shaban; Pance, Alena; Ochola-Oyier, Lynette; Kariuki, Symon; Newton, Charles; Bejon, Philip; Rayner, Julian (2023-09-28)The impact of cerebral malaria on the transcriptional profiles of cerebral tissue is difficult to study using non-invasive approaches. We isolated plasma extracellular vesicles (EVs) from patients with cerebral malaria and ... -
Novel stem cell technologies are powerful tools to understand the impact of human factors on Plasmodium falciparum malaria
Pance, Alena; Ng, Bee Ling; Mwikali, Kioko; Koutsourakis, Manousos; Agu, Chukwuma; Rouhani, Foad J.; Montandon, Ruddy; Law, Frances; Ponstingl, Hannes; Rayner, Julian C. (2023-12-19)Plasmodium falciparum parasites have a complex life cycle, but the most clinically relevant stage of the disease is the invasion of erythrocytes and the proliferation of the parasite in the blood. The influence of human ... -
Novel systems to study vector-pathogen interactions in malaria
Parres-Mercader, Marina; Pance, Alena; Gómez-Díaz, Elena (2023-05-26)Some parasitic diseases, such as malaria, require two hosts to complete their lifecycle: a human and an insect vector. Although most malaria research has focused on parasite development in the human host, the life cycle ...