Browsing Research publications by Author "Parisini, Irene"
Now showing items 1-4 of 4
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Interaction of Formulation and Device Factors Determine the In Vitro Performance of Salbutamol Sulphate Dry Powders for Inhalation
Muddle, Joanna; Murnane, Darragh; Parisini, Irene; Brown, Marc; Page, Clive; Forbes, Ben (2015-11-01)A variety of capsule-based dry powder inhalers were used to evaluate formulation-device interaction. The in vitro deposition of salbutamol sulphate (SS) was compared directly to published data for salmeterol xinafoate (SX). ... -
Mathematical approach for understanding deagglomeration behaviour of drug powder in formulations with coarse carrier
Parisini, Irene; Collett, James L.; Murnane, Darragh (2015-12-01)Deagglomeration of cohesive particles in combination with coarse carrier is a key requirement for inhaled formulations. The aim of the project was to propose a mathematical approach to understand aerosolization behaviour ... -
Potential of a cyclone prototype spacer to improve in vitro dry powder delivery
Parisini, Irene; Cheng, Sean J; Symons, Digby; Murnane, Darragh (2014-05)Purpose: Low inspiratory force in patients with lung disease is associated with poor deagglomeration and high throat deposition when using dry powder inhalers (DPIs). The potential of two reverse flow cyclone prototypes ... -
Predicting the Fine Particle Fraction of Dry Powder Inhalers Using Artificial Neural Networks
Muddle, Joanna; Kirton, Stewart B.; Parisini, Irene; Muddle, Andrew; Murnane, Darragh; Ali, Jogoth; Brown, Marc; Page, Clive; Forbes, Ben (2017-01-01)Dry powder inhalers are increasingly popular for delivering drugs to the lungs for the treatment of respiratory diseases, but are complex products with multivariate performance determinants. Heuristic product development ...