Browsing Research publications by Author "Patel, Pryank"
Now showing items 1-10 of 10
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Characterisation of the interaction of the C-terminus of the dopamine D2 receptor with neuronal calcium sensor-1
Lian, Lu-Yun; Pandalaneni, Sravan R.; Patel, Pryank; McCue, Hannah V.; Haynes, Lee P.; Burgoyne, Robert D. (2011-11-16)NCS-1 is a member of the neuronal calcium sensor (NCS) family of EF-hand Ca(2+) binding proteins which has been implicated in several physiological functions including regulation of neurotransmitter release, membrane ... -
Discovery of novel small molecule inhibitors of S100P, with in vitro anti-metastatic effects on pancreatic cancer cells
Camara, Ramatoulie; Ogbeni, Deborah; Gerstmann, Lisa; Ostovar, Mehrnoosh; Hurer, Ellie; Scott, Mark; Mahmoud, Nasir; Radon, Tomasz; Crnogorac-Jurcevic, Tatjana; Patel, Pryank; Mackenzie, Louise Susan; Chau, David; Kirton, Stewart; Rossiter, Sharon (2020-10-01)S100P, a calcium- binding protein, is known to advance tumor progression and metastasis in pancreatic and several other cancers. Herein is described the in silico identification of a putative binding pocket of S100P to ... -
Evidence that Diclofenac and Celecoxib are thyroid hormone receptor beta antagonists
Zloh, Mire; Perez Diaz, Noelia; Tang, Leslie; Patel, Pryank; MacKenzie, Louise Susan (2016-02-01)Long term use of NSAIDs is linked to side effects such as gastric bleeding and myocardial infarction. AIMS: Use of in silico methods and pharmacology to investigate the potential for NSAIDs diclofenac, celecoxib and naproxen ... -
In silico modelling of prostacyclin and other lipid mediators to nuclear receptors reveal novel thyroid hormone beta receptor antagonist properties.
Perez Diaz, Noelia; Zloh, Mire; Patel, Pryank; MacKenzie, Louise Susan (2016-01-01)Prostacyclin (PGI2) is a key mediator involved in cardiovascular homeostasis, acting predominantly on two receptor types; cell surface IP receptor and cytosolic peroxisome proliferator activated receptor (PPAR) β/δ. Having ... -
Metastasis-promoting anterior gradient 2 protein has a dimeric thioredoxin fold structure and a role in cell adhesion
Patel, Pryank; Clarke, Christopher; Barraclough, Dong Liu; Jowitt, Thomas Adam; Rudland, Philip Spencer; Barraclough, Roger; Lian, Lu-Yun (2013-03-11)Anterior gradient 2 (AGR2) is a normal endoplasmic reticulum protein that has two important abnormal functions, amphibian limb regeneration and human cancer metastasis promotion. These normal intracellular and abnormal ... -
The new CCP4 Coordinate Library as a toolkit for the design of coordinate-related applications in protein crystallography
Krissinel, E.B.; Winn, M.D.; Ballard, C.C.; Ashton, A.W.; Patel, Pryank; Potterton, E.A.; McNicholas, S.J.; Cowtan, K.D.; Emsley, P. (2004-12)The new CCP4 Coordinate Library is a development aiming to provide a common layer of coordinate-related functionality to the existing applications in the CCP4 suite, as well as a variety of tools that can simplify the ... -
Ongoing developments in CCP4 for high-throughput structure determination
Winn, M.D.; Ashton, A.W.; Briggs, P.J.; Ballard, C.C.; Patel, Pryank (2002-11)Collaborative Computational Project Number 4 (CCP4) was established in 1979 to promote collaboration between UK groups writing software for protein crystallography. From these beginnings, CCP4 now distributes a large ... -
Phosphorylation of Cysteine String Protein Triggers a Major Conformational Switch
Patel, Pryank; Prescott, Gerald R.; Burgoyne, Robert D; Lian, Lu-Yun; Morgan, Alan (2016-07-21)Cysteine string protein (CSP) is a member of the DnaJ/Hsp40 chaperone family that localizes to neuronal synaptic vesicles. Impaired CSP function leads to neurodegeneration in humans and model organisms as a result of ... -
Solution NMR structure of the Ca2+-bound N-terminal domain of CaBP7 : a regulator of golgi trafficking
McCue, Hannah V.; Patel, Pryank; Herbert, Andrew P.; Lian, Lu-Yun; Burgoyne, Robert D.; Haynes, Lee P. (2012-11-02)Calcium-binding protein 7 (CaBP7) is a member of the calmodulin (CaM) superfamily that harbors two high affinity EF-hand motifs and a C-terminal transmembrane domain. CaBP7 has been previously shown to interact with and ... -
Solution structure of the inner DysF domain of myoferlin and implications for limb girdle muscular dystrophy type 2b
Patel, Pryank; Harris, Richard; Geddes, Stella M.; Strehle, Eugen-Matthias; Watson, James D.; Bashir, Rumaisa; Bushby, Katharine; Driscoll, Paul C.; Keep, Nicholas H. (2008-06-20)Mutations in the protein dysferlin, a member of the ferlin family, lead to limb girdle muscular dystrophy type 2B and Myoshi myopathy. The ferlins are large proteins characterised by multiple C2 domains and a single ...