Browsing Research publications by Author "Pearce, N. J."
Now showing items 1-3 of 3
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The effect of (-)-hydroxycitrate and mevinolin on the activity of the low-density lipoprotein receptor and 3-hydroxy-3-methylglutaryl-coenzyme A reductase in the human hepatoma Hep G2
Berkhout, Theo; Groot, P.H.E.; Havekes, Louis M.; Pearce, N. J. (W. Zuckwerdt Verlag, 1992) -
The effect of (-)-hydroxycitrate on the activity of the low-density-lipoprotein receptor and 3-hydroxy-3-methylglutaryl-CoA reductase levels in the human hepatoma cell line Hep G2
Berkhout, Theo; Havekes, Louis M.; Pearce, N. J.; Groot, P.H.E. (1990)(-)-Hydroxycitrate, a potent inhibitor of ATP citrate-lyase, was tested in Hep G2 cells for effects on cholesterol homoeostasis. After 2.5 h and 18 h incubations with (-)-hydroxycitrate at concentrations of 0.5 mM or higher, ... -
The role of ATP citrate-lyase in the metabolic regulation of plasma lipids. Hypolipidaemic effects of SB-204990, a lactone prodrug of the potent ATP citrate-lyase inhibitor SB-201076
Pearce, N. J.; Yates, J. W.; Berkhout, Theo; Jackson, B.; Tew, D.; Boyd, H.; Camilleri, P.; Sweeney, P.; Gribble, Andrew D.; Shaw, A.; Groot, P. H. E. (1998-08-15)ATP citrate (pro-S)-lyase (EC 4.1.3.8), a cytosolic enzyme that generates acetyl-CoA for cholesterol and fatty acid synthesis de novo, is a potential target for hypolipidaemic intervention. Here we describe the biological ...