Browsing Research publications by Author "Pearce, Nigel"

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    • SR-12813 lowers plasma cholesterol in beagle dogs by decreasing cholesterol biosynthesis 

      Berkhout, Theo; Simon, Helen M.; Jackson, Brian; Yates, John; Pearce, Nigel; Groot, Pieter H E; Bentzen, Craig; Niesor, Eric; Kerns, William D.; Suckling, Keith E. (1997-09-01)
      SR-12813 inhibits cholesterol biosynthesis in Hep G2 cells via an enhanced degradation of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. Here we also show that SR-12813 inhibits cholesterol biosynthesis in vivo. ...