Browsing Research publications by Author "Pearce, R. K. B."
Now showing items 1-2 of 2
-
GDNF reverses priming for dyskinesia in MPTP-treated, L-DOPA-primed common marmosets
Iravani, Mahmoud M.; Costa, S.; Jackson, M. J.; Tel, Banu C.; Cannizzaro, C.; Pearce, R. K. B.; Jenner, P. (2001-02)Parkinson's disease (PD) is associated with a progressive loss of dopamine neurons in the substantia nigra and degeneration of dopaminergic terminals in the striatum. Although L-DOPA treatment provides the most effective ... -
Glial cell line-derived neurotrophic factor concentration dependently improves disability and motor activity in MPTP-treated common marmosets
Costa, S.; Iravani, Mahmoud M.; Pearce, R. K. B.; Jenner, P. (2001-01-19)Glial cell line-derived neurotrophic factor (GDNF) has previously reduced motor deficits and preserved nigral dopamine neurones in rhesus monkeys with a unilateral MPTP-induced lesion of substantia nigra. We now report on ...