Browsing Research publications by Author "Rossiter, S."
Now showing items 1-10 of 10
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Copper (II) mediated arylation with aryl boronic acids for the N-derivatization of pyrazole libraries
Rossiter, S.; Woo, C.K.; Hartzoulakis, B.; Wishart, G.; Stanyer, L.; Labadie, J.W.; Selwood, D.L. (2004)A N-derivatized 3-dimethylaminopropyloxypyrazole library was prepared using solution-phase parallel synthesis. The library was designed using physicochemical constraints designed to remove non-membrane-permeable molecules. ... -
Demethylation of 2,4-dimethoxquinolines: the synthesis of atanine
Jones, K.; Roset, X.; Rossiter, S.; Whitfield, P.J. (2003) -
Discovery of inhibitors of the pentein superfamily protein dimethylarginine dimethylaminohydrolase (DDAH), by virtual screening and hit analysis
Hartzoulakis, B.; Rossiter, S.; Gill, H.; Steinke, E.; Gane, P.J.; Hurtado-Guerrero, R.; Leiper, J.M.; Vallance, P.; Murray-Rust, J.; Selwood, D.L. (2007) -
Halogenated indole-3-acetic acids as oxidatively activated prodrugs with potential for targeted cancer therapy
Rossiter, S.; Folkes, L.K.; Wardman, P. (2002) -
Horseradish peroxidase-mediated gene therapy : choice of prodrugs in oxic and anoxic tumor conditions
Greco, O.; Rossiter, S.; Kanthou, C.; Folkes, L.K.; Wardman, P.; Tozer, G.M.; Dachs, G.U. (2001) -
Inhibition of dimethylarginine dimethylaminohydrolase (DDAH) and arginine deiminase (ADI) by pentafluorophenyl (PFP) sulfonates
Vallance, P.; Bush, H.D.; Mok, B.J.; Hurtado-Guerrero, R.; Gill, H.; Rossiter, S.; Wilden, J.D.; Caddick, S. (2005) -
Reactivity toward thiols and cytotoxicity of 3-methylene-2-oxindoles, cytotoxins from indole-3-acetic acids, on activation by peroxidases
Folkes, L.K.; Rossiter, S.; Wardman, P. (2002) -
Selective substrate-based inhibitors of mammalian dimethylarginine dimethylaminohydrolase
Rossiter, S.; Smith, C.L.; Malaki, M.; Nandi, M.; Gill, H.; Leiper, J.M.; Vallance, P.; Selwood, D.L. (2005)The enzyme DDAH metabolizes methylarginines that are inhibitors of nitric oxide synthase (NOS). Substrate-based inhibitors of mammalian DDAH have been synthesized, with optimization to give selective inhibition of DDAH ... -
Synthesis and anthelmintic properties of arylquinolines with activity against drug resistant nematodes
Rossiter, S.; Peron, J. M.; Whitfield, P.J.; Jones, K. (2005)