Browsing Research publications by Author "Rossiter, Sharon"
Now showing items 1-12 of 12
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Anthracene based compounds and their uses
School of Life and Medical Sciences; Natural Product Chemistry and Drug Design; Centre for Research into Topical Drug Delivery and Toxicology; Psychopharmacology, Drug Misuse and Novel Psychoactive Substances Unit; Centre for Health Services and Clinical Research; Centre for Research in Mechanisms of Disease and Drug Discovery; Department of Clinical, Pharmaceutical and Biological Science; Rossiter, Sharon; Kirton, Stewart; Camara, Ramatoulie (2016-11-17) -
Bicyclic 6-6 Systems: Pteridines
Rossiter, Sharon; Ostovar, Mehrnoosh (Elsevier, 2022)This article describes the literature on pteridines, covering the period from 2008 to 2020. The physical properties and reactions include photochemistry, substitution at ring nitrogens, nucleophilic substitution at ring ... -
A cellulose-based bioassay for the colorimetric detection of pathogen DNA
Saikrishnan, Deepika; Goyal, Madhu; Rossiter, Sharon; Kukol, A. (2014-12-01)Cellulose-paper-based colorimetric bioassays may be used at the point of sampling without sophisticated equipment. This study reports the development of a colorimetric bioassay based on cellulose that can detect pathogen ... -
A comparison of novel N(G),N(G)-disubstituted arginines on recombinant dimethylarginine dimethylaminohydrolase-1 activity and nitrite production in RAW264.7 macrophages
Morfill, Corinne; Rossiter, Sharon; Smith, Caroline (2012) -
Design, Synthesis and Antimicrobial Evaluation of the in vitro Efficacy of Novel Diketones
Garikipati, Rajesh; Mohammed, Olufunmilayo; Rossiter, Sharon; Baines, Simon; Bassin, Jatinder; Goyal, Madhu (2015-11-26)A series of novel diketones were designed and synthesised in an attempt to develop potent antimicrobial agents. Their structures were confirmed by spectroscopic techniques i.e. 1H and 13C-NMR, IR and LC-MS. The minimum ... -
Discovery of novel small molecule inhibitors of S100P, with in vitro anti-metastatic effects on pancreatic cancer cells
Camara, Ramatoulie; Ogbeni, Deborah; Gerstmann, Lisa; Ostovar, Mehrnoosh; Hurer, Ellie; Scott, Mark; Mahmoud, Nasir; Radon, Tomasz; Crnogorac-Jurcevic, Tatjana; Patel, Pryank; Mackenzie, Louise Susan; Chau, David; Kirton, Stewart; Rossiter, Sharon (2020-10-01)S100P, a calcium- binding protein, is known to advance tumor progression and metastasis in pancreatic and several other cancers. Herein is described the in silico identification of a putative binding pocket of S100P to ... -
Disruption of methylarginine metabolism impairs vascular homeostasis
Leiper, James; Nandi, Manasi; Torondel, Belen; Murray-Rust, Judith; Malaki, Mohammed; O'Hara, Bernard; Rossiter, Sharon; Anthony, Shelagh; Madhani, Melanie; Selwood, David; Smith, Caroline; Wojciak-Stothard, Beata; Rudiger, Alain; Stidwill, Ray; McDonald, Neil Q.; Vallance, Patrick (2007-02)Asymmetric dimethylarginine (ADMA) and monomethyl arginine (L-NMMA) are endogenously produced amino acids that inhibit all three isoforms of nitric oxide synthase (NOS)(1). ADMA accumulates in various disease states, ... -
Guanidine derivatives as inhibitors of DDAH
Psychopharmacology, Drug Misuse and Novel Psychoactive Substances Unit; Centre for Research in Mechanisms of Disease and Drug Discovery; Natural Product Chemistry and Drug Design; Department of Clinical, Pharmaceutical and Biological Science; Centre for Health Services and Clinical Research; School of Life and Medical Sciences; Rossiter, Sharon; Vallance, Patrick; Leiper, James; Selwood, David; Hartzoulakis, Basil (2009) -
In silico structural evaluation of short cationic antimicrobial peptides
Passarini, Ilaria; Rossiter, Sharon; Malkinson, John; Zloh, Mire (2018-06-21)Cationic peptides with antimicrobial properties are ubiquitous in nature and have been studied for many years in an attempt to design novel antibiotics. However, very few molecules are used in the clinic so far, sometimes ... -
Synthesis and evaluation of antibacterial activity of series of novel diketones
Rossiter, Sharon; Zloh, Mire; Bassin, Jatinder; Singh, Jagbir; Goyal, Madhu (2015-11-26) -
Synthesis and in silico modelling of the potential dual mechanistic activity of small cationic peptides potentiating the antibiotic novobiocin against susceptible and multi-drug resistant Escherichia coli
Passarini, Ilaria; Ernesto de Resende, Pedro; Soares, Sarah; Tahmasi, Tadeh; Stapleton, Paul; Malkinson, John; Zloh, Mire; Rossiter, Sharon (2020-11-30)Cationic antimicrobial peptides have attracted interest, both as antimicrobial agents and for their ability to increase cell permeability to potentiate other antibiotics. However, toxicity to mammalian cells and complexity ... -
Three heterocyclic rings fused (5:6:5).
Rossiter, Sharon; Hilton, Stephen (Elsevier, 2008)The chapter gives an updated overview of the many chemically and structurally diverse 5-6-5 fused tricyclic heterocyclic systems that are reported in the literature.