Browsing Research publications by Author "Vallance, Patrick"

Now showing items 1-2 of 2

    • Disruption of methylarginine metabolism impairs vascular homeostasis 

      Leiper, James; Nandi, Manasi; Torondel, Belen; Murray-Rust, Judith; Malaki, Mohammed; O'Hara, Bernard; Rossiter, Sharon; Anthony, Shelagh; Madhani, Melanie; Selwood, David; Smith, Caroline; Wojciak-Stothard, Beata; Rudiger, Alain; Stidwill, Ray; McDonald, Neil Q.; Vallance, Patrick (2007-02)
      Asymmetric dimethylarginine (ADMA) and monomethyl arginine (L-NMMA) are endogenously produced amino acids that inhibit all three isoforms of nitric oxide synthase (NOS)(1). ADMA accumulates in various disease states, ...

    • Guanidine derivatives as inhibitors of DDAH 

      Psychopharmacology, Drug Misuse and Novel Psychoactive Substances Unit; Centre for Research in Mechanisms of Disease and Drug Discovery; Natural Product Chemistry and Drug Design; Department of Clinical, Pharmaceutical and Biological Science; Centre for Health Services and Clinical Research; School of Life and Medical Sciences; Rossiter, Sharon; Vallance, Patrick; Leiper, James; Selwood, David; Hartzoulakis, Basil (2009)