Browsing Research publications by Author "Vergari, Elisa"

Now showing items 1-3 of 3

    • GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation 

      Shigeto, Makoto; Ramracheya, Reshma; Tarasov, Andrei I; Cha, Chae Young; Chibalina, Margarita V; Hastoy, Benoit; Philippaert, Koenraad; Reinbothe, Thomas; Rorsman, Nils; Salehi, Albert; Sones, William R; Vergari, Elisa; Weston, Cathryn; Gorelik, Julia; Katsura, Masashi; Nikolaev, Viacheslav O; Vennekens, Rudi; Zaccolo, Manuela; Galione, Antony; Johnson, Paul R V; Kaku, Kohei; Ladds, Graham; Rorsman, Patrik (2015-12-01)
      Strategies aimed at mimicking or enhancing the action of the incretin hormone glucagon-like peptide 1 (GLP-1) therapeutically improve glucose-stimulated insulin secretion (GSIS); however, it is not clear whether GLP-1 ...

    • Glucose stimulates somatostatin secretion in pancreatic δ-cells by cAMP-dependent intracellular Ca2+ release 

      Denwood, Geoffrey; Tarasov, Andrei; Salehi, Albert; Vergari, Elisa; Ramracheya, Reshma; Takahashi, Harumi; Nikolaev, Viacheslav O; Seino, Susumo; Gribble, Fiona; Reimann, Frank; Rorsman, Patrik; Zhang, Quan (2019-09-02)
      Somatostatin secretion from pancreatic islet δ-cells is stimulated by elevated glucose levels, but the underlying mechanisms have only partially been elucidated. Here we show that glucose-induced somatostatin secretion ...

    • Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion 

      Vergari, Elisa; Knudsen, Jakob G; Ramracheya, Reshma; Salehi, Albert; Zhang, Quan; Adam, Julie; Asterholm, Ingrid Wernstedt; Benrick, Anna; Briant, Linford J B; Chibalina, Margarita V; Gribble, Fiona M; Hamilton, Alexander; Hastoy, Benoit; Reimann, Frank; Rorsman, Nils J G; Spiliotis, Ioannis I; Tarasov, Andrei; Wu, Yanling; Ashcroft, Frances M; Rorsman, Patrik (2019-01-11)
      Hypoglycaemia (low plasma glucose) is a serious and potentially fatal complication of insulin-treated diabetes. In healthy individuals, hypoglycaemia triggers glucagon secretion, which restores normal plasma glucose levels ...