Browsing Research publications by Author "Watt, Fiona M."
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Transient activation of FOXN1 in keratinocytes induces a transcriptional programme that promotes terminal differentiation : Contrasting roles of FOXN1 and Akt
Janes, Sam M.; Ofstad, Tyler A.; Campbell, Douglas H.; Watt, Fiona M.; Prowse, David M. (2004-08-15)The forkhead transcription factor FOXN1 is required for normal cutaneous and thymic epithelial development. Mutations in FOXN1 give rise to the nude phenotype in mice, rats and man. However, the genes that are regulated ... -
Transient activaton of β-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours
Celso, Cristina Lo; Prowse, David M.; Watt, Fiona M. (2004-04-01)When β-catenin signalling is disturbed from mid-gestation onwards lineage commitment is profoundly altered in postnatal mouse epidermis. We have investigated whether adult epidermis has the capacity for β-catenin-induced ... -
β-catenin and hedgehog signal strength can specify number and location of hair follicles in adult epidermis without recruitment of bulge stem cells
Silva-Vargas, Violeta; Lo Celso, Cristina; Giangreco, Adam; Ofstad, Tyler; Prowse, David M.; Braun, Kristin M.; Watt, Fiona M. (2005-07-01)Using K14ΔNβ-cateninER transgenic mice, we show that short-term, low-level β-catenin activation stimulates de novo hair follicle formation from sebaceous glands and interfollicular epidermis, while only sustained, high-level ...