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Design, Synthesis and SAR Exploration of Tri-substituted 1,2,4-Triazoles as Inhibitors of the Annexin A2-S100A10 Protein Interaction
(2014-10-01)
Recent target validation studies have shown that inhibition of the protein interaction between annexin A2 and the S100A10 protein may have potential therapeutic benefits in cancer. Virtual screening identified certain ...
Transverse strength of railway tracks : Part 2. Test system for ballast resistance in line measurement
(2014-10-01)
In the present paper, testing methods currently adopted to measure the in service ballast resistance are synthetically reviewed to identify the main sources of uncertainty influencing the test loads and to define an ...
On the turbulent flow models in modelling of omni-flow wind turbine
(2014-10)
The computational fluid dynamics (CFD) has a wide application in the wind energy industry. In CFD simulations, a turbulence model plays a significantly important role in accuracy and resource cost. In this paper, a novel ...
Health Assessment Questionnaire disability progression in early rheumatoid arthritis : systematic review and analysis of two inception cohorts
(2014-10)
The Health Assessment Questionnaire is widely used in patients with inflammatory polyarthritis (IP) and its subset rheumatoid arthritis (RA). In this study we evaluated the progression of HAQ scores in RA by (i) systematically ...
Transverse strength of railway tracks : Part 3. Multiple scenarios test field
(2014-10-01)
In the present paper the design and construction choices of a test field for the ballast lateral resistance measurement, in order to produce data useful for the development of a numerical model able to simulate the service ...
Opinion of AG Sharpston (12 December 2013) and Grand Chamber Judgment (12 March 2014) in Cases C-456/12 O and B and C-457/12 S and G
(2014-10-01)
The relationship between third-country national family members of Union citizens, fundamental rights and Union citizenship rights has been unclear since the Zambrano ruling in 2011. Several years later, the Court of Justice ...
Dynamics and Energy Loss in Superbubbles
(2014-10-01)
Interstellar bubbles appear to be smaller in observations than expected from calculations. Instabilities at the shell boundaries create three-dimensional (3D) effects and are probably responsible for part of this discrepancy. ...
A 3D extinction map of the northern Galactic plane based on IPHAS photometry
(2014-10-01)
We present a 3D map of extinction in the northern Galactic plane derived using photometry from the INT/WFC Photometric Hα Survey of the northern Galactic plane. The map has fine angular (~10 arcmin) and distance (100 pc) ...
Derivation of the action and symmetries of the q-deformed AdS5×S5 superstring
(2014-10)
We recently proposed an integrable q-deformation of the AdS5 × S 5 superstring action. Here we give details on the hamiltonian origin and construction of this deformation. The procedure is a generalization of the one ...
The Meaningful Exposition
(Leiden University Press, 2014-10)