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Amphiphilic poly(l-amino acids) : New materials for drug delivery
The formulation of drug compounds into medicines will increasingly rely on the use of specially tailored molecules, which fundamentally alter the drug's pharmacokinetics to enable its therapeutic activity. This is particularly ...
A prodrug nanoparticle approach for the oral delivery of a hydrophilic peptide, leucine(5)-enkephalin, to the brain
The oral use of neuropeptides to treat brain disease is currently not possible because of a combination of poor oral absorption, short plasma half-lives and the blood-brain barrier. Here we demonstrate a strategy for ...
The effect of polymer architecture on the nano self-assemblies based on novel comb-shaped amphiphilic poly(allylamine)
Twelve novel poly(allylamine) (PAA)-based, comb-shaped amphiphilic polymers have been developed. Hydrophobic groups of cetyl, palmitoyl and cholesteryl were randomly grafted to PAA and quaternisation was carried out on ...