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Exploring the Association Between Suicidal Thoughts, Self-Injury, and GLP-1 Receptor Agonists in Weight Loss Treatments: Insights from Pharmacovigilance Measures and Unmasking Analysis
(2024-05)
Introduction: The study addresses concerns about potential psychiatric side effects of Glucagon-like peptide-1 receptor agonists (GLP-1 RA). Aim: The aim of this work was to analyse adverse drug reports (ADRs) from the ...
Semaglutide as a Possible Calmodulin Binder: Ligand-Based Computational Analyses and Relevance to Its Associated Reward and Appetitive Behaviour Actions
(2024-03-22)
Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, has gained considerable attention as a therapeutic agent for type 2 diabetes mellitus and obesity. Despite its clinical success, the precise mechanisms ...
Benefits and Harms of 'Smart Drugs' (Nootropics) in Healthy Individuals
(2022-04-02)
‘Smart drugs’ (also known as ‘nootropics’ and ‘cognitive enhancers’ [CEs]) are being used by healthy subjects (i.e. students and workers) typically to improve memory, attention, learning, executive functions and vigilance, ...
New Psychoactive Substances (NPS) and Serotonin Syndrome onset: a Systematic Review
(2021-05-01)
The use of several new psychoactive substances (NPS) has become very popular and is posing global health risks. Chemically and pharmacologically diverse molecules are constantly emerging and are presenting with a wide range ...
Misuse of prescription and over-the-counter drugs to obtain illicit highs: how pharmacists can prevent abuse
(2020-11-18)
There have been increasing reports of misuse of a range of prescription and over-the-counter (OTC) drugs for recreational purposes. The use of psychoactive pharmaceuticals and ‘pharming’ are new, widespread phenomena ...
COVID-19: The hidden impact on mental health and drug addiction
(2020-07-29)
There is concern the Coronavirus Disease (COVID)-19 pandemic is having a negative impact on the mental health of the general population through a range of suggested mechanisms: fear, uncertainty, and anxiety; social ...
Exploring the baseline knowledge and experience of healthcare professionals in the United Kingdom on Novel Psychoactive Substances
(2020-03-02)
Objective: This survey aimed to explore knowledge and experience on novel psychoactive substances (NPS) of healthcare professionals (HCPs). The study also aimed to assess how HCPs would like to improve their knowledge of ...
'New/Designer Benzodiazepines': an analysis of the literature and psychonauts’ trip reports
(2020-01-10)
Background: NPS belonging to the benzodiazepine (BZD) class, e.g., ‘legal/designer BZDs’/‘research chemicals’, have recently emerged in the drug (mainly online/virtual) market. Objective: While certain NPS belonging to the ...
Substance Use Disorders and Violence
(Springer International Publishing AG, part of Springer Nature, 2020-01-01)
Substance use seems to be associated with increased prevalence levels of violent behaviour in both general population and psychiatric patients, with ‘dual-diagnosis’ clients showing high rates of risky and criminal behaviour ...