Search
Now showing items 1-1 of 1
Effects of a novel lanosterol 14α-demethylase inhibitor on the regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in Hep G2 cells
(1991-12-10)
A 32-carboxylic acid derivative of lanosterol (SKF 104976) was found to be a potent inhibitor of lanosterol 14α-demethylase (14αDM). 14αDM activity in a Hep G2 cell extract was inhibited 50% by 2 nM SKF 104976. Exposure ...