Now showing items 11-19 of 19
Variability in human skin permeability in vitro: Comparing penetrants with different physicochemical properties
Appreciating and compensating for the inherent variability associated with percutaneous absorption is essential in optimizing (trans)dermal therapy. In this study, the variability in human skin permeability associated with ...
Topical buparvaquone formulations for the treatment of cutaneous leishmaniasis
As the part of a study to develop buparvaquone (BPQ) formulations for the treatment of cutaneous leishmaniasis, the topical delivery of BPQ and one of its prodrugs from a range of formulations was evaluated. In previous ...
Schistosome cercarial interactions with human keratinocytes and langerhans cells
The human parasite, Schistosoma mansoni is known to modulate host immune responses in order to promote its own survival. However, studies investigating the interaction between the skin-invading cercarial stage and cells ...
The lost science of formulation
The current R&D outsourcing market is growing annually at ∼15%, with a predicted market of US$36 billion by 2010. However, top tier contract research organizations (CROs) are attempting to transform their profitability by ...
In vivo evaluation of novel hyaluronan/chitosan microparticulate delivery systems for the nasal delivery of gentamicin in rabbits
Biodegradable microparticles containing gentamicin were prepared using chitosan hydroglutamate (CH), hyaluronic acid (HA) and a combination Of both polymers by a solvent evaporation method. These formulations were administered ...
Protective mechanism of stabilising excipients against dehydration in the freeze-drying of proteins
To investigate the influence of type and amount of excipient on the preservation of the native structure and the biologic activity of freeze-dried lysozyme and catalase
An in vitro investigation into the effect of glycosaminoglycans on the skin partitioning and deposition of NSAIDs
Recently, Solaraze gel (Bioglan, Herts, UK) a topical hyaluronan (HA)/dictofenac formulation for the treatment of actinic keratosis has received regulatory approval in the US, Canada and Europe for the treatment of actinic ...
Preparation and evaluation of the in vitro drug release properties and mucoadhesion of novel microspheres of hyaluronic acid and chitosan
Rapid mucociliary clearance of intranasally administered drugs is often a key factor in determining the bioavailability of such therapeutic agents. The use of mucoadhesive microparticles provide a potential strategy for ...