Now showing items 31-40 of 61
An evaluation of the potential of linear and nonlinear skin permeation models for the prediction of experimentally measured percutaneous drug absorption
Objectives: The developments in combinatorial chemistry have led to a rapid increase in drug design and discovery and, ultimately, the production of many potential molecules that require evaluation. Hence, there has been ...
5,6-Methylenedioxy-2-aminoindane : from laboratory curiosity to 'legal high'
The fully synthetic 'legal high' 5,6-methylenedioxy-2-aminoindane (MDAI) is an analogue of 3,4-methylenedioxymethamphetamine. Although developed in the 1990s, it was not widely abused until 2010. However, mephedrone was ...
Lipopolysaccharide-induced nigral inflammation leads to increased IL-1β tissue content and expression of astrocytic glial cell line-derived neurotrophic factor.
Reactive gliosis and inflammatory change is a key component of nigral dopaminergic cell death in Parkinson's disease (PD). Astrocyte derived glial cell line-derived neurotrophic factor (GDNF) promotes the survival and ...
A review of the evidence for the effects of total dietary fat, saturated, monounsaturated and n-6 polyunsaturated fatty acids on vascular function, endothelial progenitor cells and microparticles
Vascular dysfunction is recognised as an integrative marker of CVD. While dietary strategies aimed at reducing CVD risk include reductions in the intake of SFA, there are currently no clear guidelines on what should replace ...
Failure Mode and Effects Analysis : views of hospital staff in the UK
To explore health care professionals' experiences and perceptions of Failure Mode and Effects Analysis (FMEA), a team-based, prospective risk analysis technique.
Molecular and Cellular Therapeutics
(Wiley Blackwell, 2012)
Molecular and Cellular Therapeutics aims to bring together key developments in the areas of molecular diagnostics, therapeutics and drug discovery. The book covers topics including diagnostics, therapeutics, model systems, ...
Perfusion CT assessment of the colon and rectum : Feasibility of quantification of bowel wall perfusion and vascularization
The aim was to determine the feasibility of vascular quantification of the bowel wall for different anatomical segments of the colorectum. Following institutional ethical approval and informed consent, 39 patients with ...
Comparison of Pelvic Complex Kinematics During Treadmill and Overground Walking
OBJECTIVES: To determine if there are changes in temporal gait parameters with a focus on pelvis when comparing overground and treadmill ambulation, and to assess the effect of sex. DESIGN: An observational study employing ...
An investigative study into the influence of a commercially available carbohydrate-protein-electrolyte beverage on short term repeated exercise performance
Background: The purpose of this study was to undertake an independent investigation into the effects of ingesting a carbohydrate-protein-electrolyte (CPE) beverage on repeated submaximal and time-trial cycling performance. ...
Characterising wide spatial variation in population size structure of a keystone African savanna tree
Elephant impact on trees is of conservation concern in African savannas, but it’s effect on population size structure of heavily utilised species has received little attention. Although studies have shown that the population ...