Now showing items 1-5 of 5
Nail swelling as a pre-formulation screen for the selection and optimisation of ungual penetration enhancers
Introduction. Targeting drug treatment to fungal infections that reside within or below the nail plate is problematic due to the highly restrictive barrier of the human nail. To optimise topical formulations for ungual ...
Immunomodulatory effects of schistosome cercarial interactions with human keratinocytes and Langerhans cells
The human parasite Schistosoma mansoni is known to modulate host immune responses in order to promote its own survival. However, studies investigating the interaction between the skin-invading cercarial stage and cells of ...
Variability in human skin permeability in vitro: Comparing penetrants with different physicochemical properties
Appreciating and compensating for the inherent variability associated with percutaneous absorption is essential in optimizing (trans)dermal therapy. In this study, the variability in human skin permeability associated with ...
Topical buparvaquone formulations for the treatment of cutaneous leishmaniasis
As the part of a study to develop buparvaquone (BPQ) formulations for the treatment of cutaneous leishmaniasis, the topical delivery of BPQ and one of its prodrugs from a range of formulations was evaluated. In previous ...