Now showing items 1-9 of 9
The application of Gaussian processes in the prediction of percutaneous absorption
Objectives The aim was to assess mathematically the nature of a skin permeability dataset and to determine the utility of Gaussian processes in developing a predictive model for skin permeability, comparing it with existing ...
Transient drug supersaturation kinetics of beclomethasone dipropionate in rapidly drying films
Supersaturation is an effective method to enhance the delivery of active compounds into the skin, however the long-term instability of the drug in these formulations that exceed thermodynamic unity prevents clinical use. ...
An investigation into solvent-membrane interactions when assessing drug release from organic vehicles using regenerated cellulose membranes
The influence of organic solvents on artificial membranes when assessing drug release from topical formulations is, generally, poorly characterised yet current guidelines require no characterisation of the membrane before, ...
Effect of abrasion induced by a rotating brush on the skin permeation of solutes with varying physicochemical properties
A transient reduction in the barrier nature of the skin can be a pre-requisite for successful (trans)dermal delivery of some drugs. The aim of this present study was to investigate and effect of a dermal abrading "rotating ...
The lost science of formulation
The current R&D outsourcing market is growing annually at ∼15%, with a predicted market of US$36 billion by 2010. However, top tier contract research organizations (CROs) are attempting to transform their profitability by ...
In vivo evaluation of novel hyaluronan/chitosan microparticulate delivery systems for the nasal delivery of gentamicin in rabbits
Biodegradable microparticles containing gentamicin were prepared using chitosan hydroglutamate (CH), hyaluronic acid (HA) and a combination Of both polymers by a solvent evaporation method. These formulations were administered ...
Protective mechanism of stabilising excipients against dehydration in the freeze-drying of proteins
To investigate the influence of type and amount of excipient on the preservation of the native structure and the biologic activity of freeze-dried lysozyme and catalase
An in vitro investigation into the effect of glycosaminoglycans on the skin partitioning and deposition of NSAIDs
Recently, Solaraze gel (Bioglan, Herts, UK) a topical hyaluronan (HA)/dictofenac formulation for the treatment of actinic keratosis has received regulatory approval in the US, Canada and Europe for the treatment of actinic ...