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Selective discrimination learning impairments in mice expressing the human Huntington's disease mutation
Cognitive decline is apparent in the early stages of Huntington's disease and progressively worsens throughout the course of the disease. Expression of the human Huntington's disease mutation in mice (R6/2 line) causes a ...
Novel selective compounds for the investigation of imidazoline receptors
Over several years our group has sought to synthesize and identify selective ligands for imidazoline (I) receptors, in particular the I2 binding site. As a consequence, [3H]2-(2-benzofuranyl)-2-imidazoline (2BFI) has proved ...
Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation
Transgenic mice expressing exon 1 of the human Huntington's disease (HD) gene carrying a 141-157 CAG repeat (line R6/2) develop a progressive neurological phenotype with motor symptoms resembling those seen in HD. We have ...
Characterization of imidazoline receptors by radioligand binding
(Humana Press, 1999)