Search
Now showing items 1-10 of 1051
Aryldiketo acids have antibacterial activity against MDR Staphylococcus aureus strains : Structural insights based on similarity and molecular interaction fields
(2009-12-07)
(Chemical Equation Presented) Similar structure=similar activity? The effect of substituents on the antibacterial activity of aryldiketo acids has been rationalised by molecular interaction fields and similarity studies ...
The effect of phenyl substituents on C NMR shifts and metal ions binding to 4-Phenyl-2,4-dioxobutanoic acid derivatives
(2009-12-01)
Butanoic moiety of 4-aryl-2,4-dioxobutanoic acids is involved in interactions with metal ions within HIV-1 integrase active site. Sixteen congeneric 4-phenyl-2,4-dioxobutanoic acid derivatives with different substitution ...
Doing interdisciplinarity : motivation and collaboration in research for sustainable agriculture in the UK
(2009-12)
This paper studies knowledge production in complex, collaborative research projects that brought together academics from different disciplines, research users and agricultural businesses. It takes a comparative approach, ...
Validity, reliability and acceptability of the Imperial Nutritional Screening System (INSYST) : A tool that does not require the body mass index
(2009-12)
Background: Nutritional screening tools are central to identifying malnourished patients, but their efficacy is often reduced as a result of difficulties in obtaining height for body mass index (BMI) calculations. The ...
Pollination biology of fruit-bearing hedgerow plants and the role of flower-visiting insects in fruit-set
(2009-12)
In the UK, the flowers of fruit-bearing hedgerow plants provide a succession of pollen and nectar for flower-visiting insects for much of the year. The fruits of hedgerow plants are a source of winter food for frugivorous ...
Human papillomavirus is detected in transitional cell carcinoma arising in renal transplant recipients
(2009-11-09)
Aims: We investigated the role of human papillomavirus HPV in the development of transitional cell carcinoma TCC arising in renal transplant recipients. Methods: Genomic DNA was extracted from 10 m paraffin embedded sections ...
Simultaneous monitoring of drug and solvent diffusion across a model membrane using ATR-FTIR spectroscopy
(2009-11-05)
Attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy has been used to simultaneously follow the diffusion of model drugs and solvent across polydimethylsiloxane (silicone) membrane. Three model ...
Plant defensins : defense, development and application
(2009-11)
Plant defensins are small, highly stable, cysteine-rich peptides that constitute a part of the innate immune system primarily directed against fungal pathogens. Biological activities reported for plant defensins include ...
Large-scale analysis of Influenza A virus sequences reveals potential drug-target sites of non-structural proteins
(2009-10)
The non-structural protein 1 (NS1) of the influenza A virus and the NS2 protein, which is also known as nuclear export protein, play important roles in the infectious life cycle of the virus. The objective of this study ...
Continuous administration of rotigotine to MPTP-treated common marmosets enhances anti-parkinsonian activity and reduces dyskinesia induction
(2009-10)
Rotigotine is a novel, non-ergoline dopamine D-3/D-2/D-1-receptor agonist for the treatment of Parkinson's disease that can be Continuously delivered by the transdermal route to provide stable plasma levels. Continuous ...