Now showing items 1-10 of 11
An Interneuron Circuit Reproducing Essential Spectral Features of Field Potentials
Recent advances in engineering and signal processing have renewed the interest in invasive and surface brain recordings, yet many features of cortical field potentials remain incompletely understood. In the present ...
Temporal integration and 1/f power scaling in a circuit model of cerebellar interneurons
Inhibitory interneurons interconnected via electrical and chemical (GABAA receptor) synapses form extensive circuits in several brain regions. They are thought to be involved in timing and synchronization through fast ...
Nonspecific synaptic plasticity improves the recognition of sparse patterns degraded by local noise
Many forms of synaptic plasticity require the local production of volatile or rapidly diffusing substances such as nitric oxide. The nonspecific plasticity these neuromodulators may induce at neighboring non-active synapses ...
Impaired facial emotion recognition in patients with ventromedial prefrontal hypoperfusion
Empathy refers to our ability to recognize and share emotions by another human being. Impairment may underlie many of the emotional deficits commonly associated with a range of neuropsychiatric and neurological conditions. ...
Multiplicative gain modulation arising from inhibitory synaptic plasticity in the cerebellar nuclei
Neurons use the rate of action potentials to encode sensory variables. This makes the output rate as a function of input, also known as input-output (I–O) relationship, a core computational function in neuronal processing. ...
Endogenous cholinergic inputs and local circuit mechanisms govern the phasic mesolimbic dopamine response to nicotine
Nicotine exerts its reinforcing action by stimulating nicotinic acetylcholine receptors (nAChRs) and boosting dopamine (DA) output from the ventral tegmental area (VTA). Recent data have led to a debate about the principal ...
Short-term depression of inhibitory Purkinje cell synapses enhances gain modulation in the cerebellar nuclei
Poster presented at CNS 2013
Determinants of associative memory performance in spiking and non-spiking neural networks with different synaptic plasticity regimes
Poster presented at CNS 2012
STD-dependent and independent encoding of input irregularity as spike rate in a computational model of a cerebellar nucleus neuron
Neurons in the cerebellar nuclei (CN) receive inhibitory inputs from Purkinje cells in the cerebellar cortex and provide the major output from the cerebellum, but their computational function is not well understood. It has ...