Research publications: Recent submissions
Now showing items 6561-6580 of 9764
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Dealing with diversity : cross-cultural aspects of the near death experiences
(Jessica Kingsley Publishers, 2011) -
The Urashima effect : a cultural illusion?
(Nova Science Publishers, 2009) -
Bloggers Beware!
(2007-12-07)A consideration of the implications in the case of Sheffield Wednesday Football Club v Neil Hargreaves. -
Exploring space consciousness and other dissociative experiences : A Japanese perspective
(2010-01-01)The field of consciousness studies has long benefitted from the investigation of non-ordinary states of consciousness, both spontaneous and facilitated by mind-altering agents. In the present study, I look at the implications ... -
Closing down a means of collective voice for workers : Victimisation of union activists in Britain’
(2011)This article examines the incidence and nature of employer victimisation of labour union activists in Britain between 1998 and 2009. It finds that the incidence is higher than is expected, shows signs of rising, and is ... -
Ford V Fordism : The Beginning of Mass production
(Edward Elgar Publishing, 2006)This article questions the stereotypes of Fordism and mass production. It does so by demonstrating that there is a contradiction between the stereotypes and the reality of Henry Ford's manufacturing practice in production ... -
A financialized account of corporate governance
(Palgrave Macmillan, 2008)The debate on international business behaviour is located within a “productionist” framework which is used to reveal similarities and differences in the corporate governance of multinational business. A “financialized” ... -
Identification of metabolites of a substance P (NK1 receptor) antagonist in rat hepatocytes and rat plasma
(2002-01-01)The metabolism of a substance P (NK1 receptor) antagonist in rat hepatocytes and rat plasma was described. The samples were prepared for analysis by protein precipitation followed by centrifugation. It was shown that the ... -
A New Pyridazine Series of GABAA α5 Ligands
(2005-09-22)Screening of the Merck compound collection identified 6 as an unusually simple, low molecular weight hit with moderate affinity for GABAA receptors. The structural novelty of 6, compared to our advanced series of GABAA α5 ... -
Aryl sulfones : A new class of γ-secretase inhibitors
(2005-05-16)The development of a novel series of 4-aryl, 4-phenylsulfonyl cyclohexananone-derived γ-secretase inhibitors for the potential treatment of Alzheimer's disease is described -
Metabolite identification in drug discovery
(2003-01-01)Recent developments in the technologies and approaches to identify metabolites in a drug discovery environment are reviewed. Samples may be generated using either in vitro systems - typically, but not exclusively, liver ... -
Identification of metabolites of a substance P (Neurokinin 1 receptor) antagonist in rat hepatocytes and rat plasma
(2002-01-01)[3R,5R,6S]-3-(2-cyclopropyloxy-5-trifluoromethoxyphenyl)-6-phenyl-1-oxa-7 -azaspiro[4.5]decane is a substance P (Neurokinin 1 receptor) antagonist. Substance P antagonists are proven in concept to have excellent potential ... -
Synthesis and conformational dynamics of tricyclic pyridones containing a fused seven-membered ring
(2002-12-27)A new synthetic approach to tricyclic pyridones bearing a fused seven-membered ring is described. These compounds exhibit atropisomerism and exist in enantiomeric forms. Chiral HPLC separation of the enantiomers has allowed ... -
Neighboring group participation of the indole nucleus : An unusual DAST-mediated rearrangerment reaction
(2000-08-11)A rearrangement reaction involving the indole nucleus was investigated using stereochemical markers and low-temperature NMR experiments. Treatment of(3S,4S)-3-hydroxy-4-(2-phenyl-1H-indol-3-yl)-piperidine-1-carboxylic acid ... -
Synthesis of conformationally constrained analogues of BRL32872 : Determination of stereochemistry and related pharmacological properties
(1997-08-05)2-Azabicyclo[2.2.2]octane derivatives have been used as conformationally constrained structure of BRL-32872, in order to investigate the effect of molecular flexibility towards class III and class IV antiarrhythmic properties. ... -
Two conformers of the glycopeptide antibiotic teicoplanin with distinct ligand binding sites
(1995-01-01)The clinically important vancomycin group glycopeptide antibiotics, which act by blocking cell wall synthesis, are crucial in the treatment of methicillin resistant Staphylococcus aureus. All of the group members studied ... -
Dissection of the contributions toward dimerization of glycopeptide antibiotics
(1994-06-01)A procedure for the determination of association constants in aqueous solution using hydrogen-deuterium exchange has been developed and used to measure the dimerization constant, K(dim), for a number of strongly dimerizing ...