Research publications: Recent submissions
Now showing items 8501-8520 of 9764
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Alpha-blockade and calcium antagonism : an effective and well-tolerated combination for the treatment of resistant hypertension
(1995)Objective: To test whether the combination of calcium antagonism is additive with the other newer antihypertensives, namely [alpha]-blockers and angiotensin converting enzyme (ACE) inhibitors. Design: Three-way double-blind, ... -
Bovril and moclobemide: a novel therapeutic strategy for central autonomic failure
(1994)The consumption of tyramine-containing foods is contraindicated in patients on classic monoamine oxidase (MAO) inhibitors. We report successful therapeutic use of moclobemide (a MAO-A selective inhibitor) plus controlled ... -
Optimisation of antihypertensive treatment by crossover rotation of four major classes
(1999)Most comparisons of antihypertensive drugs aee undertaken in parallel groups. We undertook a crossover rotation of the four main classes of antihypertensive drugs, in untreated young hypertensive patients, to assess the ... -
[beta]2-Adrenoceptor gene polymorphisms and blood pressure variations in East Anglian Caucasians
(2000)Objective: The amino-terminal polymorphisms, Arg16Gly and Gln27Glu, of the [beta]2-adrenergic receptor ([beta]2AR) have been shown to affect regulation of the receptor expression by an agonist in cell culture studies. The ... -
The gain-of-function G389R variant of the β1-adrenoceptor does not influence blood pressure or heart rate response to β-blockade in hypertensive subjects
(2000)Mutation scanning of the b1-adrenoceptor gene has identified a polymorphism, G389R, that markedly affects G-protein coupling of the receptor and resulting cAMP production. We have investigated the effect of this functionally ... -
Association of the Gsα Gene With Essential Hypertension and Response to ß-Blockade
(1999)We examined whether the GNAS1 locus, encoding the Gs protein α-subunit (Gsα), is implicated in the genetic causes of essential hypertension. A common silent polymorphism (ATTATC, Ile131) was identified in exon 5 of the Gsα ... -
A prospective study of the effects of prolonged timolol therapy on α- and β-adrenoceptor and angiotensin II receptor mediated responses in normal subjects
(1997)Aims Long-term treatment with β1-selective adrenergic antagonists gives rise to cross-sensitisation of cardiac β2-adrenoceptor responses, with no corresponding alteration in β1-adrenoceptor responses. We performed a ... -
Beta adrenoreceptor subtype cross regulation in the human heart
(1993)OBJECTIVES--To find out in a prospective study whether beta 1 blocker treatment causes selective beta 2 adrenoreceptor sensitisation, and to find whether such sensitisation is confined to the heart. DESIGN--A placebo ... -
Prolonged effect of CGRP in Raynaud's patients : a double-blind randomised comparison with prostacyclin
(1991)1. Calcitonin gene related peptide (CGRP) is a potent endogenous vasodilator to which we have previously demonstrated a specific hypersensitivity in skin blood flow in the hands in patients with Raynaud's disease. 2. We ... -
A sensitive radioimmunoassay measuring endothelin-like immunoreactivity in human plasma : comparison of levels in patients with essential hypertension and normotensive control subjects
(1990)1. A radioimmunoassay has been developed for measuring endothelin-like immunoreactivity in human plasma using an antibody raised against endothelin-1 which also cross-reacts with big endothelin-1 and endothelin-2 but not ... -
Selective suprasensitivity to calcitonin-gene-related peptide in the hands in Raynaud's phenomenon
(1989)The effects of intravenous infusion of three vasodilators on skin blood flow were studied in eight patients with Raynaud's phenomenon and eight controls, matched for age and sex, by means of the non-invasive technique of ... -
HAT-P-14b: A 2.2Mj exoplanet transiting a bright F star
(2010)We report the discovery of HAT-P-14b, a fairly massive transiting extrasolar planet orbiting the moderately bright star GSC 3086-00152 (V = 9.98), with a period of P = 4.627669 ± 0.000005 days. The transit is close to ... -
Laxative use in care homes
(2010)Aim. This paper is a report of an investigation into the factors associated with laxative-taking by older people in care homes. Background. Constipation is a common source of discomfort, pain and morbidity for care home ... -
Using Web 2.0 Technologies to Engage With and Support the net Generation of Learners
(2007)Web 2.0 social software offer new pedagogic opportunities to support and empower the Net generation of learners to create their own personal learning agenda and dynamic learning environments. This paper presents learners ... -
Avoiding plagiarism in academic writing
(2009)Plagiarism means taking the work of another and presenting it as one’s own, resulting in potential upset for the original author and disrepute for the professions involved. This article aims to explore the issue of plagiarism ... -
Authoritarian vs authoritative teaching : Polya and Lakatos
(Springer Nature Link, 2010)How can a teacher be authoritative without being authoritarian? Throughout his adult life, Lakatos campaigned against authoritarian teaching on both scientific and political grounds, without always disentangling the two. ... -
A multiwavelength study of star formation in the vicinity of galactic H II region Sh 2-100
(2010)We present multiwavelength investigation of morphology, physical-environment, stellar contents, and star formation activity in the vicinity of star-forming region Sh 2-100. It is found that the Sh 2-100 region contains ... -
Measurement issues in the sonographic assessment of tennis elbow
(2010)Sonography is increasingly being used for assessment in tennis elbow research and clinical practice, but there are a lack of data regarding its validity, reliability, and responsiveness to change for this application. ... -
GRB 090902B: afterglow observations and implications
(2010)The optical-infrared afterglow of the Large Area Telescope (LAT)-detected long-duration burst, GRB 090902B, has been observed by several instruments. The earliest detection by ROTSE-IIIa occurred 80 minutes after detection ...