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dc.contributor.authorSchifano, Fabrizio
dc.contributor.authorCorkery, John
dc.contributor.authorGilvarry, Eilish
dc.contributor.authorDeluca, Paolo
dc.contributor.authorOyefeso, Adenekan
dc.contributor.authorGhodse, A. Hamid
dc.identifier.citationSchifano , F , Corkery , J , Gilvarry , E , Deluca , P , Oyefeso , A & Ghodse , A H 2005 , ' Buprenorphine mortality, seizures and prescription data in the UK, 1980-2002 ' , Human Psychopharmacology , vol. 20 , no. 5 , pp. 343-8 .
dc.identifier.otherPURE: 307394
dc.identifier.otherPURE UUID: 9c2f10b8-26e3-4eb9-a15e-2972f735cfa3
dc.identifier.otherPubMed: 15957155
dc.identifier.otherScopus: 23244441626
dc.descriptionDue to publisher restrictions the full text of this article is not available in the UHRA
dc.description.abstractBuprenorphine safety in overdose has been debated recently, but no mortality data related to this compound from the UK have been published. To gather together all of the buprenorphine mortality figures, a number of different sources have been checked. To inform on buprenorphine safety issues, accessible information related to its availability indicators (i.e. prescriptions; seizures) data for the 1980-2002 time frame have been sought. In the UK, during this period, buprenorphine was mentioned in 43 fatalities. Typically, victims were males in the 25-44 age group. In 12 cases (28% of total), a verdict of suicide was given. Buprenorphine was detected on its own in seven cases; more frequently, it was found together with benzodiazepines and other opiates. Large quantities of buprenorphine were prescribed both in England in 1985-1989 and in 1991-1992 in Scotland, where seizures reached their highest levels. Buprenorphine prescriptions seemed to peak again after 1999, when high dose buprenorphine formulations entered the UK market. No positive correlation was found between the number of buprenorphine deaths over the years and either buprenorphine dispensings/prescriptions or seizures. However, an increase in buprenorphine-related deaths since 1999 was identified and this may be an issue which should be carefully monitored over the next few years.en
dc.relation.ispartofHuman Psychopharmacology
dc.subjectDrug Utilization
dc.subjectGreat Britain
dc.subjectMiddle Aged
dc.subjectTime Factors
dc.titleBuprenorphine mortality, seizures and prescription data in the UK, 1980-2002en
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.description.statusPeer reviewed
rioxxterms.typeJournal Article/Review

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