dc.contributor.author | Han, D.D. | |
dc.contributor.author | Tian, Y.T. | |
dc.contributor.author | Zhang, T. | |
dc.contributor.author | Ren, Guogang | |
dc.contributor.author | Yang, Z. | |
dc.date.accessioned | 2011-08-15T14:01:10Z | |
dc.date.available | 2011-08-15T14:01:10Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | Han , D D , Tian , Y T , Zhang , T , Ren , G & Yang , Z 2011 , ' Nano-zinc oxide damages spatial cognition capability via over-enhanced long-term potentiation in hippocampus of Wistar rats ' , International Journal of Nanomedicine , vol. 6 , pp. 1453-1461 . https://doi.org/10.2147/IJN.S18507 | |
dc.identifier.issn | 1176-9114 | |
dc.identifier.other | ORCID: /0000-0001-8865-1526/work/32373270 | |
dc.identifier.uri | http://hdl.handle.net/2299/6219 | |
dc.description | Original article can be found at : http://www.dovepress.com/ Copyright Dove Medical Press | |
dc.description.abstract | This study focused on the effects of zinc oxide nanoparticles (nano-ZnO) on spatial learning and memory and synaptic plasticity in the hippocampus of young rats, and tried to interpret the underlying mechanism. Rats were randomly divided into four groups. Nano-ZnO and phosphate-buffered saline were administered in 4-week-old rats for 8 weeks. Subsequently, performance in Morris water maze (MWM) was determined, and then long-term potentiation (LTP) and depotentiation were measured in the perforant pathway to dentate gyrus (DG) in anesthetized rats. The data showed that, the escape latency was prolonged and LTP was significantly enhanced in the nano-ZnO group, while depotentiation was barely influenced in the DG region in the same group. This bidirectional effect on long-term synaptic plasticity broke the balance between stability and flexibility of cognition. The spatial learning and memory ability was attenuated by the alteration of synaptic plasticity induced by nano ZnO particles. | en |
dc.format.extent | 8 | |
dc.format.extent | 527973 | |
dc.language.iso | eng | |
dc.relation.ispartof | International Journal of Nanomedicine | |
dc.subject | zinc oxide nanoparticles | |
dc.subject | synaptic plasticity | |
dc.subject | long-term potentiation | |
dc.subject | depotentiation | |
dc.subject | spatial learning | |
dc.subject | memory | |
dc.title | Nano-zinc oxide damages spatial cognition capability via over-enhanced long-term potentiation in hippocampus of Wistar rats | en |
dc.contributor.institution | School of Engineering and Technology | |
dc.contributor.institution | Science & Technology Research Institute | |
dc.description.status | Peer reviewed | |
rioxxterms.versionofrecord | 10.2147/IJN.S18507 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |