| dc.contributor.author | Liu, Z. | |
| dc.contributor.author | Liu, S. | |
| dc.contributor.author | Ren, Guogang | |
| dc.contributor.author | Zhang, T. | |
| dc.contributor.author | Yang, Z. | |
| dc.date.accessioned | 2011-08-31T10:01:02Z | |
| dc.date.available | 2011-08-31T10:01:02Z | |
| dc.date.issued | 2011 | |
| dc.identifier.citation | Liu , Z , Liu , S , Ren , G , Zhang , T & Yang , Z 2011 , ' Nano-CuO inhibited voltage-gated sodium current of hippocampal CA1 neurons via reactive oxygen species but independent from G-proteins pathway ' , Journal of Applied Toxicology , vol. 31 , no. 5 , pp. 439-445 . https://doi.org/10.1002/jat.1611 | |
| dc.identifier.issn | 0260-437X | |
| dc.identifier.other | ORCID: /0000-0001-8865-1526/work/32373271 | |
| dc.identifier.uri | http://hdl.handle.net/2299/6365 | |
| dc.description | The definitive version can be found at: http://onlinelibrary.wiley.com/ Copyright Wiley-Blackwell [Full text of this article is not available in the UHRA] | |
| dc.description.abstract | The aim of this study was to investigate the effects of nano-CuO on voltage-gated sodium current (INa) in hippocampal CA1 neurons. The results suggested that nano-CuO inhibited amplitudes of INa currents and prolonged peak rise time of action potential (AP). The responses to nano-CuO were inhibited by reactive oxygen species (ROS) scavenger. However, the G-proteins inhibitor did not block the effects of nano-CuO. The effects of nano-CuO were mediated through activation of ROS-INa-AP signaling cascades and independent from G-proteins pathway. | en |
| dc.language.iso | eng | |
| dc.relation.ispartof | Journal of Applied Toxicology | |
| dc.subject | hippocampus | |
| dc.subject | nano-CuO | |
| dc.subject | reactive oxygen species | |
| dc.subject | voltage-gated sodium current | |
| dc.title | Nano-CuO inhibited voltage-gated sodium current of hippocampal CA1 neurons via reactive oxygen species but independent from G-proteins pathway | en |
| dc.contributor.institution | Materials and Structures | |
| dc.contributor.institution | School of Physics, Engineering & Computer Science | |
| dc.contributor.institution | Department of Engineering and Technology | |
| dc.contributor.institution | Centre for Engineering Research | |
| dc.contributor.institution | Centre for Future Societies Research | |
| dc.contributor.institution | BioEngineering | |
| dc.description.status | Peer reviewed | |
| rioxxterms.versionofrecord | 10.1002/jat.1611 | |
| rioxxterms.type | Journal Article/Review | |
| herts.preservation.rarelyaccessed | true | |
