Show simple item record

dc.contributor.authorLiu, Z.
dc.contributor.authorLiu, S.
dc.contributor.authorRen, Guogang
dc.contributor.authorZhang, T.
dc.contributor.authorYang, Z.
dc.date.accessioned2011-08-31T10:01:02Z
dc.date.available2011-08-31T10:01:02Z
dc.date.issued2011
dc.identifier.citationLiu , Z , Liu , S , Ren , G , Zhang , T & Yang , Z 2011 , ' Nano-CuO inhibited voltage-gated sodium current of hippocampal CA1 neurons via reactive oxygen species but independent from G-proteins pathway ' , Journal of Applied Toxicology , vol. 31 , no. 5 , pp. 439-445 . https://doi.org/10.1002/jat.1611
dc.identifier.issn0260-437X
dc.identifier.otherPURE: 344825
dc.identifier.otherPURE UUID: 4ccd4d36-fc8a-44d8-82a4-18e002567e81
dc.identifier.otherScopus: 79960706489
dc.identifier.otherORCID: /0000-0001-8865-1526/work/32373271
dc.identifier.urihttp://hdl.handle.net/2299/6365
dc.descriptionThe definitive version can be found at: http://onlinelibrary.wiley.com/ Copyright Wiley-Blackwell [Full text of this article is not available in the UHRA]
dc.description.abstractThe aim of this study was to investigate the effects of nano-CuO on voltage-gated sodium current (INa) in hippocampal CA1 neurons. The results suggested that nano-CuO inhibited amplitudes of INa currents and prolonged peak rise time of action potential (AP). The responses to nano-CuO were inhibited by reactive oxygen species (ROS) scavenger. However, the G-proteins inhibitor did not block the effects of nano-CuO. The effects of nano-CuO were mediated through activation of ROS-INa-AP signaling cascades and independent from G-proteins pathway.en
dc.language.isoeng
dc.relation.ispartofJournal of Applied Toxicology
dc.subjecthippocampus
dc.subjectnano-CuO
dc.subjectreactive oxygen species
dc.subjectvoltage-gated sodium current
dc.titleNano-CuO inhibited voltage-gated sodium current of hippocampal CA1 neurons via reactive oxygen species but independent from G-proteins pathwayen
dc.contributor.institutionSchool of Engineering and Technology
dc.contributor.institutionScience & Technology Research Institute
dc.description.statusPeer reviewed
rioxxterms.versionofrecordhttps://doi.org/10.1002/jat.1611
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record