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dc.contributor.authorJoseph, S. R. H.
dc.contributor.authorSteuber, Volker
dc.contributor.authorWillshaw, D. J.
dc.contributor.editorBower, James M.
dc.date.accessioned2011-09-29T15:01:03Z
dc.date.available2011-09-29T15:01:03Z
dc.date.issued1997
dc.identifier.citationJoseph , S R H , Steuber , V & Willshaw , D J 1997 , The dual role of calcium in synaptic plasticity at the motor endplate . in J M Bower (ed.) , Computational neuroscience: trends in research, 1997 . PLENUM PRESS DIV PLENUM PUBLISHING CORP , NEW YORK , pp. 712 , Procs of the 5th Annual Computational Neuroscience Conference , Boston , United States , 14/07/96 .
dc.identifier.citationconference
dc.identifier.isbn0-306-45699-0
dc.identifier.isbn978-0-306-45699-2
dc.identifier.otherPURE: 381419
dc.identifier.otherPURE UUID: 15c16ff0-04a5-49b8-90e9-24f4d5c31cf7
dc.identifier.otherWOS: A1997BJ84S00002
dc.identifier.urihttp://hdl.handle.net/2299/6538
dc.descriptionFull text of this paper is not available in UHRA
dc.description.abstractFocal blockade of postsynaptic acetylcholine receptors (AChRs) in a small region of the neuromuscular junction may cause long-term synapse elimination at that site. Blockade of the whole junction does not cause synapse loss, indicating that it is the contrast in postsynaptic activity between the blocked and unblocked regions which causes withdrawal of the synaptic terminals. This phenomenon can be explained by the dual role of calcium, both in controlling AChR gene transcription and influencing AChR aggregation. A computational model is provided and the stability of the solutions is confirmed by theoretical analysis and computer simulation.en
dc.format.extent6
dc.language.isoeng
dc.publisherPLENUM PRESS DIV PLENUM PUBLISHING CORP
dc.relation.ispartofComputational neuroscience: trends in research, 1997
dc.titleThe dual role of calcium in synaptic plasticity at the motor endplateen
dc.contributor.institutionSchool of Computer Science
dc.contributor.institutionScience & Technology Research Institute
dc.contributor.institutionCentre for Computer Science and Informatics Research
dc.relation.schoolSchool of Computer Science
dcterms.dateAccepted1997
rioxxterms.typeOther
herts.preservation.rarelyaccessedtrue


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