| dc.contributor.author | Joseph, S. R. H. | |
| dc.contributor.author | Steuber, Volker | |
| dc.contributor.author | Willshaw, D. J. | |
| dc.contributor.editor | Bower, James M. | |
| dc.date.accessioned | 2011-09-29T15:01:03Z | |
| dc.date.available | 2011-09-29T15:01:03Z | |
| dc.date.issued | 1997 | |
| dc.identifier.citation | Joseph , S R H , Steuber , V & Willshaw , D J 1997 , The dual role of calcium in synaptic plasticity at the motor endplate . in J M Bower (ed.) , Computational neuroscience: trends in research, 1997 . PLENUM PRESS DIV PLENUM PUBLISHING CORP , NEW YORK , pp. 712 , Procs of the 5th Annual Computational Neuroscience Conference , Boston , United States , 14/07/96 . | |
| dc.identifier.citation | conference | |
| dc.identifier.isbn | 0-306-45699-0 | |
| dc.identifier.isbn | 978-0-306-45699-2 | |
| dc.identifier.other | ORCID: /0000-0003-0186-3580/work/133139218 | |
| dc.identifier.uri | http://hdl.handle.net/2299/6538 | |
| dc.description | Full text of this paper is not available in UHRA | |
| dc.description.abstract | Focal blockade of postsynaptic acetylcholine receptors (AChRs) in a small region of the neuromuscular junction may cause long-term synapse elimination at that site. Blockade of the whole junction does not cause synapse loss, indicating that it is the contrast in postsynaptic activity between the blocked and unblocked regions which causes withdrawal of the synaptic terminals. This phenomenon can be explained by the dual role of calcium, both in controlling AChR gene transcription and influencing AChR aggregation. A computational model is provided and the stability of the solutions is confirmed by theoretical analysis and computer simulation. | en |
| dc.format.extent | 6 | |
| dc.language.iso | eng | |
| dc.publisher | PLENUM PRESS DIV PLENUM PUBLISHING CORP | |
| dc.relation.ispartof | Computational neuroscience: trends in research, 1997 | |
| dc.title | The dual role of calcium in synaptic plasticity at the motor endplate | en |
| dc.contributor.institution | Centre for Computer Science and Informatics Research | |
| dc.contributor.institution | Department of Computer Science | |
| dc.contributor.institution | School of Physics, Engineering & Computer Science | |
| dc.contributor.institution | Centre of Data Innovation Research | |
| dc.contributor.institution | Centre for Future Societies Research | |
| dc.contributor.institution | Biocomputation Research Group | |
| rioxxterms.type | Other | |
| herts.preservation.rarelyaccessed | true | |
